, Volume 249, Issue 11, pp 1535-1540

Circadian heart rate variability in Parkinson's disease

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Abstract.

Parkinson's disease is known to affect the reflex cardiovascular control systems, resulting in a suppressed heart rate variability, but present knowledge concerning the long-term characteristics of heart rate and heart rate variability, e. g. circadian regulation, is limited.

We investigated the circadian fluctuation of the time domain, frequency domain and some non-linear measures of heart rate variability in 44 untreated patients with Parkinson's disease and 43 age- and sex-matched control subjects.

In the parkinsonian patients, the measured power spectral components of heart rate variability (low-frequency power and high-frequency power) and the SD1 value of the Poincaré two dimensional vector analysis, that quantifies the short term beat-to-beat variability, were suppressed at night. During the daytime only the SD1 of the Poincaré was suppressed. The night-to-day-ratios of the heart rate variability measures did not differ significantly between the patients and the controls.

The results indicate that the long-term parasympathetic cardiovascular regulation is impaired in untreated patients with Parkinson's disease. The dysfunction is more pronounced at night.

Received: 21 January 2002, Received in revised form: 14 May 2002, Accepted: 22 May 2002
Correspondence to Ville Pursiainen