Journal of Neurology

, Volume 249, Issue 11, pp 1493–1502

Skeletal muscle channelopathies

  • Karin Jurkat-Rott
  • Holger Lerche
  • Frank Lehmann-Horn
ENS TEACHING REVIEW

DOI: 10.1007/s00415-002-0871-5

Cite this article as:
Jurkat-Rott, K., Lerche, H. & Lehmann-Horn, F. J Neurol (2002) 249: 1493. doi:10.1007/s00415-002-0871-5

Abstract.

Ion channelopathies have common clinical features, recurrent patterns of mutations, and almost predictable mechanisms of pathogenesis. In skeletal muscle, disorders are associated with mutations in voltage-gated Na+, K+, Ca2+, and Cl channels leading to hypoexcitability, causing periodic paralysis and to hyperexcitabilty, resulting in myotonia or susceptibility to malignant hyperthermia.

Key words ionchannelshereditary diseasessodiumpotassiumcalcium chloride

Copyright information

© Steinkopff Verlag 2002

Authors and Affiliations

  • Karin Jurkat-Rott
    • 1
  • Holger Lerche
    • 1
  • Frank Lehmann-Horn
    • 1
  1. 1.Department of Applied Physiology, University of Ulm, 89069 Ulm, GermanyDE
  2. 2.Department of Neurology, University of Ulm, 89069 Ulm, GermanyDE