Journal of Neurology

, Volume 249, Issue 9, pp 1246–1249

Impaired salivary gland function reveals autonomic dysfunction in amyotrophic lateral sclerosis

  • Ralf Giess
  • Edgar Werner
  • Marcus Beck
  • Christoph Reiners
  • Klaus Victor Toyka
  • Markus Naumann
Original Communication

DOI: 10.1007/s00415-002-0820-3

Cite this article as:
Giess, R., Werner, E., Beck, M. et al. J Neurol (2002) 249: 1246. doi:10.1007/s00415-002-0820-3

Abstract

Recent studies have revealed autonomic dysfunction in amyotrophic lateral sclerosis (ALS). We studied salivary gland function by quantitative scintigraphy in ALS patients (n = 30) and healthy controls (n = 30). Uptake of 99mTc-pertechnetate in the parotid and submandibular glands was significantly decreased in ALS patients. No correlation was found between radiotracer uptake and regions of onset (bulbar-limb), duration of disease, or functional scores. Our data show early subclinical autonomic involvement supporting the view that ALS is a multisystem degenerative disease.

Key words Amyotrophic Lateral Sclerosisautonomic dysfunctionbotulinum toxin Asalivary glands

Copyright information

© Steinkopff Verlag 2002

Authors and Affiliations

  • Ralf Giess
    • 1
  • Edgar Werner
    • 2
  • Marcus Beck
    • 1
  • Christoph Reiners
    • 2
  • Klaus Victor Toyka
    • 1
  • Markus Naumann
    • 1
  1. 1.Department of Neurology, University of Wuerzburg, Würzburg, GermanyGermany
  2. 2.Department of Nuclear Medicine, Bayerische Julius-Maximilians-University, Würzburg, GermanyGermany
  3. 3.Henriettenstiftung, Akademisches Lehrkrankenhaus der Medizinischen Hochschule Hannover, Schwemannstraße 19, 30559 Hannover. ralf.giess@mail.uni-wuerzburg.deGermany