, Volume 249, Issue 9, pp 1246-1249
Date: 13 Jul 2014

Impaired salivary gland function reveals autonomic dysfunction in amyotrophic lateral sclerosis

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Recent studies have revealed autonomic dysfunction in amyotrophic lateral sclerosis (ALS). We studied salivary gland function by quantitative scintigraphy in ALS patients (n = 30) and healthy controls (n = 30). Uptake of 99mTc-pertechnetate in the parotid and submandibular glands was significantly decreased in ALS patients. No correlation was found between radiotracer uptake and regions of onset (bulbar-limb), duration of disease, or functional scores. Our data show early subclinical autonomic involvement supporting the view that ALS is a multisystem degenerative disease.

Received: 11 December 2001, Received in revised form: 5 March 2002, Accepted: 11 March 2002