, Volume 249, Issue 9, pp 1246-1249
Date: 13 Jul 2014

Impaired salivary gland function reveals autonomic dysfunction in amyotrophic lateral sclerosis

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

Recent studies have revealed autonomic dysfunction in amyotrophic lateral sclerosis (ALS). We studied salivary gland function by quantitative scintigraphy in ALS patients (n = 30) and healthy controls (n = 30). Uptake of 99mTc-pertechnetate in the parotid and submandibular glands was significantly decreased in ALS patients. No correlation was found between radiotracer uptake and regions of onset (bulbar-limb), duration of disease, or functional scores. Our data show early subclinical autonomic involvement supporting the view that ALS is a multisystem degenerative disease.

Received: 11 December 2001, Received in revised form: 5 March 2002, Accepted: 11 March 2002