Impaired salivary gland function reveals autonomic dysfunction in amyotrophic lateral sclerosis
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- Giess, R., Werner, E., Beck, M. et al. J Neurol (2002) 249: 1246. doi:10.1007/s00415-002-0820-3
Recent studies have revealed autonomic dysfunction in amyotrophic lateral sclerosis (ALS). We studied salivary gland function by quantitative scintigraphy in ALS patients (n = 30) and healthy controls (n = 30). Uptake of 99mTc-pertechnetate in the parotid and submandibular glands was significantly decreased in ALS patients. No correlation was found between radiotracer uptake and regions of onset (bulbar-limb), duration of disease, or functional scores. Our data show early subclinical autonomic involvement supporting the view that ALS is a multisystem degenerative disease.