Journal of Neurology

, Volume 249, Issue 6, pp 754–758

Central and peripheral nervous system functions are independently disturbed in HIV-1 infected patients

  • Hans-Jürgen von Giesen
  • Hubertus Köller
  • Harald Hefter
  • Gabriele Arendt
ORIGINAL COMMUNICATION

DOI: 10.1007/s00415-002-0707-3

Cite this article as:
von Giesen, H., Köller, H., Hefter, H. et al. J Neurol (2002) 249: 754. doi:10.1007/s00415-002-0707-3

Abstract.

We examined the peripheral nervous system (PNS) (nerve conduction velocity (NCV)) and the central nervous system (CNS) (basal ganglia-mediated psychomotor speed) in 93 males seropositive for human immunodeficiency virus type 1 (HIV-1) with no prior history of opportunistic brain disease, antiretroviral treatment or intravenous drug use. Patients with different degrees of slowing of peroneal and sural NCV showed no significant differences in psychomotor speed as assessed by tremor peak frequency, most rapid alternating movements, reaction times and contraction times. There was no significant correlation between psychomotor measures and NCV. Psychomotor slowing test findings were independent from peripheral nervous system damage indicating uncorrelated disturbances of CNS and PNS function in HIV-1 infection. Differences in HIV-1 viral quasispecies or host responses may determine the predominance of CNS or PNS injury.

Key words HIV-1central nervous systempsychomotor slowingperipheral nervous systemnerve conduction velocity

Copyright information

© Steinkopff Verlag 2002

Authors and Affiliations

  • Hans-Jürgen von Giesen
    • 1
  • Hubertus Köller
    • 1
  • Harald Hefter
    • 1
  • Gabriele Arendt
    • 1
  1. 1.Department of Neurology, Heinrich Heine University of Düsseldorf, Postfach 10 10 07, 40001 Düsseldorf, Germany. Tel.: +49-2 11/81-1 89 75, Fax: +49-2 11/81-1 84 84, E-Mail: giesenhj@uni-duesseldorf.deDE