International Journal of Legal Medicine

, Volume 111, Issue 3, pp 124–132

Population data for 101 Austrian Caucasian mitochondrial DNA d-loop sequences: Application of mtDNA sequence analysis to a forensic case

Authors

  • W. Parson
    • Institute for Forensic Medicine, University of Innsbruck, Muellerstrass 44, A-6020 Innsbruck, Austria
  • T. J. Parsons
    • The Armed Forces DNA Identification Laboratory, Armed Forces Institute of Pathology, 1413 Research Blvd., Rockville, Maryland, USA 20 850D3125
  • R. Scheithauer
    • Institute for Forensic Medicine, University of Innsbruck, Muellerstrass 44, A-6020 Innsbruck, Austria
  • M. M. Holland
    • The Armed Forces DNA Identification Laboratory, Armed Forces Institute of Pathology, 1413 Research Blvd., Rockville, Maryland, USA 20 850D3125
Original article

DOI: 10.1007/s004140050132

Cite this article as:
Parson, W., Parsons, T., Scheithauer, R. et al. Int J Leg Med (1998) 111: 124. doi:10.1007/s004140050132

Abstract

The sequence of the two hypervariable segments of the mitochondrial DNA (mtDNA) control region was generated for 101 random Austrian Caucasians. A total of 86 different mtDNA sequences was observed, where 11 sequences were shared by more than 1 individual, 7 sequences were shared by 2 individuals and 4 sequences were shared by 3 individuals. One of the four most common mtDNA sequences in Austrians is also the most common sequence in both U.S. and British Caucasians, found in approximately 3.0% of Austrians, 4.0% of British, and 3.9% of U.S. Caucasians. Of the remaining three common Austrian sequences, one was not observed in either U.S. or British Caucasians. However, three British Caucasians exhibited a similar sequence type. Therefore, this particular cluster of sequence polymorphisms may represent a common “European” mtDNA sequence type. In general, Austrian Caucasians show little deviation from other Caucasian databases of European descent. Finally, mtDNA sequence analysis was applied to a forensic case, where hairs found at a crime scene matched the control hairs from the suspect.

Key words Mitochondrial DNAHeteroplasmymtDNAPopulation frequency estimatesForensiccasework
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Copyright information

© Springer-Verlag Berlin Heidelberg 1998