International Journal of Legal Medicine

, Volume 110, Issue 3, pp 118–124

The Y chromosome in forensic analysis and paternity testing

  • M. A. Jobling
  • A. Pandya
  • C. Tyler-Smith
Review article

DOI: 10.1007/s004140050050

Cite this article as:
Jobling, M., Pandya, A. & Tyler-Smith, C. Int J Leg Med (1997) 110: 118. doi:10.1007/s004140050050

Abstract

The male specificity of the human Y chromosome makes it potentially useful in forensic studies and paternity testing, and markers are now available which will allow its usefulness to be assessed in practice. However, while it can be used confidently for exclusions, the unusual properties of the Y mean that inclusions will be very difficult to make: haplotypes are confined within lineages, so population sub-structuring is a major problem, and many male relatives of a suspect will share his Y chromosome. Y haplotyping is most likely to find application in special instances, such as deficiency cases in paternity testing and in the analysis of mixtures of male and female DNA, or in combination with autosomal markers.

Key words Y chromosome Polymorphism Haplotype Exclusion Paternity testing 

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • M. A. Jobling
    • 1
  • A. Pandya
    • 2
  • C. Tyler-Smith
    • 2
  1. 1.Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, UK FAX: +44 (116) 252 3378 e-mail: maj4@leicester.ac.ukGB
  2. 2.CRC Chromosome Molecular Biology Group, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK FAX: +44 (1865) 275 283 e-mail: chris@bioch.ox.ac.ukGB