International Journal of Legal Medicine

, Volume 127, Issue 2, pp 369–372

Mutation rates at 16 Y-chromosome STRs in the South China Han population

  • Weixia Weng
  • Hong Liu
  • Shuanglin Li
  • Jianye Ge
  • Huijun Wang
  • Chao Liu
Short Communication

DOI: 10.1007/s00414-012-0786-3

Cite this article as:
Weng, W., Liu, H., Li, S. et al. Int J Legal Med (2013) 127: 369. doi:10.1007/s00414-012-0786-3

Abstract

Nine hundred eighteen DNA-confirmed father–son pairs were typed for 16 Y-chromosomal short tandem repeat (Y-STR) markers by AmpFLSTR® Yfiler™ PCR Amplification kit. In a total of 15,606 allele transmissions, 36 mutations were detected. The average mutation rate across all 16 Y-STR markers was 0.0023 (95 % confidence interval, 0.0016–0.0032). One two-step mutation was found at DYS389II, and all other mutations were single steps. The losses and gains were balanced at all other loci, excluding DYS385 and DYS458, where losses were more frequent than gains. Mutation rates among different Y-STR loci were significantly different (Χ2 = 69.05, P = 0.000). Mutation rates were correlated with the lengths of the alleles. Alleles with higher number of repeats were more likely to mutate. Mutation rates were also correlated with the gene diversity of the locus (r2 = 0.565, P = 0.023). Loci with higher gene diversity had higher mutation rates. In addition, the mutation rate of the older father was found to be notably higher than that of the younger father.

Keywords

Y-STRsMutation ratesSouth China Han population

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Weixia Weng
    • 1
  • Hong Liu
    • 2
  • Shuanglin Li
    • 2
  • Jianye Ge
    • 3
  • Huijun Wang
    • 1
  • Chao Liu
    • 1
    • 2
  1. 1.Institute of Forensic MedicineSouthern Medical UniversityGuangzhouChina
  2. 2.Guangzhou Forensic InstituteGuangzhouChina
  3. 3.Institute of Applied Genetics, Department of Forensic and Investigative GeneticsUniversity of North Texas Health Science CenterFort WorthUSA