Original Article

International Journal of Legal Medicine

, Volume 120, Issue 6, pp 355-359

First online:

Expression of heat-shock protein 70 (Hsp70) in the respiratory tract and lungs of fire victims

  • S. MarschallAffiliated withInstitute of Legal Medicine, Albert Ludwig University
  • , M. A. RothschildAffiliated withInstitute of Legal Medicine, University of Cologne
  • , M. BohnertAffiliated withInstitute of Legal Medicine, Albert Ludwig University Email author 

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Abstract

Immunohistochemical investigation of the respiratory tract and lungs of 63 fire victims revealed a statistically significant enhanced expression of heat-shock protein 70 (Hsp70) in the epiglottis, the trachea, and the main and the peripheral bronchi compared with a control group. In the fire victims, a strong expression of Hsp70 was discernible not only particularly in the vessels but also in seromucous secretory cells, ciliated epithelial cells, smooth muscle cells, and alveolar cells. The results suggest a vital or supravital reaction due to the inhalation of hot fire fumes.

Keywords

Heat-shock protein Hsp70 Fire victims Airways Lungs