Is the amelogenin gene reliable for gender identification in forensic casework and prenatal diagnosis?
- K. ThangarajAffiliated withCenter for Cellular and Molecular Biology
- , A. G. ReddyAffiliated withCenter for Cellular and Molecular Biology
- , L. SinghAffiliated withCenter for Cellular and Molecular Biology Email author
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
In humans, the amelogenin gene is present on both the X and the Y chromosomes. However, there are size differences in this gene between these chromosomes, which have been utilised for sexing in forensic casework and prenatal diagnosis. Our study using the AmpFl STR Profiler Plus kit, showed a deletion of Y chromosome-specific amelogenin in five Indian males (1.85%). We propose to call them “deleted-amelogenin males” (DAMs), who but for the detection of the presence of other Y-specific markers (e.g. SRY, STR and 50f2) would have been identified as females. Considering the consequences of the result obtained only using the amelogenin marker, we suggest the use of additional Y chromosome markers for unambiguous gender identification.
KeywordsAmelogenin Gender identification Haplotype STR Y chromosome
- Is the amelogenin gene reliable for gender identification in forensic casework and prenatal diagnosis?
International Journal of Legal Medicine
Volume 116, Issue 2 , pp 121-123
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Gender identification
- Y chromosome
- Industry Sectors