Chromosoma

, Volume 108, Issue 2, pp 114–120

Broken chromosomal ends can be elongated by conversion in Drosophila melanogaster

Authors

  • Stanislav Mikhailovsky
    • Department of the Control of Genetic Processes, Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov St., 117334 Moscow, Russia
  • Tatyana Belenkaya
    • Department of the Control of Genetic Processes, Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov St., 117334 Moscow, Russia
  • Pavel Georgiev
    • Department of the Control of Genetic Processes, Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov St., 117334 Moscow, Russia

DOI: 10.1007/s004120050358

Cite this article as:
Mikhailovsky, S., Belenkaya, T. & Georgiev, P. Chromosoma (1999) 108: 114. doi:10.1007/s004120050358

Abstract.

The fate of the termini of X chromosomes broken in the regulatory region of the yellow gene was followed in heterozygotes with X chromosomes carrying a point mutation inactivating the yellow gene. Each generation had a loss of about 70 terminal base pairs from the broken chromosome. However, gene conversion restoring the correct sequence at the chromosomal terminus took place with a frequency of about 1×10–2 per generation. The average length of the conversion track was 2.7 kb. No recombination events occurred. In addition, we found that the normal functioning of the yellow body and wing enhancers located at the tip of the chromosome required about 4 kb of additional upstream sequence.

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© Springer-Verlag Berlin Heidelberg 1999