Chromosoma

, Volume 108, Issue 2, pp 114–120

Broken chromosomal ends can be elongated by conversion in Drosophila melanogaster

  • Stanislav Mikhailovsky
  • Tatyana Belenkaya
  • Pavel Georgiev

DOI: 10.1007/s004120050358

Cite this article as:
Mikhailovsky, S., Belenkaya, T. & Georgiev, P. Chromosoma (1999) 108: 114. doi:10.1007/s004120050358

Abstract.

The fate of the termini of X chromosomes broken in the regulatory region of the yellow gene was followed in heterozygotes with X chromosomes carrying a point mutation inactivating the yellow gene. Each generation had a loss of about 70 terminal base pairs from the broken chromosome. However, gene conversion restoring the correct sequence at the chromosomal terminus took place with a frequency of about 1×10–2 per generation. The average length of the conversion track was 2.7 kb. No recombination events occurred. In addition, we found that the normal functioning of the yellow body and wing enhancers located at the tip of the chromosome required about 4 kb of additional upstream sequence.

Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • Stanislav Mikhailovsky
    • 1
  • Tatyana Belenkaya
    • 1
  • Pavel Georgiev
    • 1
  1. 1.Department of the Control of Genetic Processes, Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov St., 117334 Moscow, RussiaRU
  2. 2.Biomedical Unit of the Oslo University in Moscow, Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov St., 117334 Moscow, RussiaRU