Chromosoma

, Volume 118, Issue 3, pp 279–290

Monoallelic gene expression in mammals

Authors

  • Irina S. Zakharova
    • Siberian Department, Institute of Cytology and GeneticsRussian Academy of Sciences
  • Alexander I. Shevchenko
    • Siberian Department, Institute of Cytology and GeneticsRussian Academy of Sciences
    • Siberian Department, Institute of Cytology and GeneticsRussian Academy of Sciences
    • Institute of Cytology and Genetics
Review

DOI: 10.1007/s00412-009-0206-8

Cite this article as:
Zakharova, I.S., Shevchenko, A.I. & Zakian, S.M. Chromosoma (2009) 118: 279. doi:10.1007/s00412-009-0206-8

Abstract

Three systems of monoallelic gene expression in mammals are known, namely, X-chromosome inactivation, imprinting, and allelic exclusion. In all three systems, monoallelic expression is regulated epigenetically and is frequently directed by long non-coding RNAs (ncRNAs). This review briefs all three systems of monoallelic gene expression in mammals focusing on chromatin modifications, spatial chromosome organization in the nucleus, and the functioning of ncRNAs.

Copyright information

© Springer-Verlag 2009