Monoallelic gene expression in mammals
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- Zakharova, I.S., Shevchenko, A.I. & Zakian, S.M. Chromosoma (2009) 118: 279. doi:10.1007/s00412-009-0206-8
Three systems of monoallelic gene expression in mammals are known, namely, X-chromosome inactivation, imprinting, and allelic exclusion. In all three systems, monoallelic expression is regulated epigenetically and is frequently directed by long non-coding RNAs (ncRNAs). This review briefs all three systems of monoallelic gene expression in mammals focusing on chromatin modifications, spatial chromosome organization in the nucleus, and the functioning of ncRNAs.