Chromosoma

, 115:175

Chiasma formation: chromatin/axis interplay and the role(s) of the synaptonemal complex

Review

DOI: 10.1007/s00412-006-0055-7

Cite this article as:
Kleckner, N. Chromosoma (2006) 115: 175. doi:10.1007/s00412-006-0055-7

Abstract

Meiotic recombination proceeds in biochemical complexes that are physically associated with underlying chromosome structural axes. In this study, we discuss the organizational basis for these axes, the timing and nature of recombinosome/axis organization with respect to the prophase program of DNA and to structural changes, and the possible significance of axis organization. Furthermore, we discuss implications and extensions of our recently proposed mechanical model for chiasma formation. Finally, we give a broader consideration to past and present models for the role of the synaptonemal complex.

Abbreviations

L

leptotene

Z

zygotene

P

pachytene

EP

early pachytene

MP

middle pachytene

LP

late pachytene

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  1. 1.Herchel Smith Professor of Molecular BiologyHarvard UniversityCambridgeUSA