, Volume 115, Issue 3, pp 175-194

Chiasma formation: chromatin/axis interplay and the role(s) of the synaptonemal complex

  • Nancy KlecknerAffiliated withHerchel Smith Professor of Molecular Biology, Harvard University Email author 

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Meiotic recombination proceeds in biochemical complexes that are physically associated with underlying chromosome structural axes. In this study, we discuss the organizational basis for these axes, the timing and nature of recombinosome/axis organization with respect to the prophase program of DNA and to structural changes, and the possible significance of axis organization. Furthermore, we discuss implications and extensions of our recently proposed mechanical model for chiasma formation. Finally, we give a broader consideration to past and present models for the role of the synaptonemal complex.