Chromosoma

, Volume 113, Issue 8, pp 409–417

Rephrasing anaphase: separase FEARs shugoshin

Mini-Review

DOI: 10.1007/s00412-005-0331-y

Cite this article as:
Stemmann, O., Boos, D. & Gorr, I.H. Chromosoma (2005) 113: 409. doi:10.1007/s00412-005-0331-y

Abstract

Cleavage of the ring-like cohesin complex by separase triggers segregation of sister chromatids in anaphase. This simplistic model has recently been extended by exciting discoveries on three levels: regulation of anaphase by posttranslational modifications and the cohesin protector shugoshin; non-proteolytic roles of separase; and cohesin-independent linkage of sister chromatids.

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  1. 1.Department of Molecular Cell BiologyMax Planck Institute of BiochemistryMartinsriedGermany