A new view of radiation-induced cancer: integrating short- and long-term processes. Part I: Approach
Mathematical models of radiation carcinogenesis are important for understanding mechanisms and for interpreting or extrapolating risk. There are two classes of such models: (1) long-term formalisms that track pre-malignant cell numbers throughout an entire lifetime but treat initial radiation dose–response simplistically and (2) short-term formalisms that provide a detailed initial dose–response even for complicated radiation protocols, but address its modulation during the subsequent cancer latency period only indirectly. We argue that integrating short- and long-term models is needed. As an example of this novel approach, we integrate a stochastic short-term initiation/inactivation/repopulation model with a deterministic two-stage long-term model. Within this new formalism, the following assumptions are implemented: radiation initiates, promotes, or kills pre-malignant cells; a pre-malignant cell generates a clone, which, if it survives, quickly reaches a size limitation; the clone subsequently grows more slowly and can eventually generate a malignant cell; the carcinogenic potential of pre-malignant cells decreases with age.
- A new view of radiation-induced cancer: integrating short- and long-term processes. Part I: Approach
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Radiation and Environmental Biophysics
Volume 48, Issue 3 , pp 263-274
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- 1. Center for Radiological Research, Columbia University Medical Center, 630 West 168th St., New York, NY, 10032, USA
- 2. Caritas St. Elizabeth’s Medical Center, Tufts University School of Medicine, Boston, MA, USA
- 3. Departments of Mathematics and Physics, University of California Berkeley, Berkeley, CA, USA