Lung

, Volume 192, Issue 4, pp 525–532

ADAM33 Gene Polymorphisms are Associated with the Risk of Idiopathic Pulmonary Fibrosis

Authors

  • Soo-Taek Uh
    • Division of Allergy and Respiratory MedicineSoonchunhyang University Hospital
  • An-Soo Jang
    • Genome Research Center for Allergy and Respiratory DiseaseSoonchunhyang University Bucheon Hospital
  • Sung-Woo Park
    • Genome Research Center for Allergy and Respiratory DiseaseSoonchunhyang University Bucheon Hospital
  • Jong-Sook Park
    • Genome Research Center for Allergy and Respiratory DiseaseSoonchunhyang University Bucheon Hospital
  • Chang-Gi Min
    • Genome Research Center for Allergy and Respiratory DiseaseSoonchunhyang University Bucheon Hospital
  • Yong Hoon Kim
    • Division of Respiratory MedicineSoonchunhyang University
  • Byung-Lae Park
    • Department of Genetic EpidemiologySNP-Genetics Inc.
  • Hyoung Doo Shin
    • Department of Genetic EpidemiologySNP-Genetics Inc.
    • Department of Life ScienceSogang University
  • Dong Soon Kim
    • Division of Pulmonary and Critical Care Medicine, Asan Medical CenterUniversity of Ulsan
    • Genome Research Center for Allergy and Respiratory DiseaseSoonchunhyang University Bucheon Hospital
    • Division of Allergy and Respiratory Medicine, Department of Internal MedicineSoonchunhyang University Bucheon Hospital
Article

DOI: 10.1007/s00408-014-9578-5

Cite this article as:
Uh, S., Jang, A., Park, S. et al. Lung (2014) 192: 525. doi:10.1007/s00408-014-9578-5

Abstract

Background

Idiopathic pulmonary fibrosis (IPF) is characterized by progressive dyspnea and worsening lung function due to remodeling of the lung, including epithelial mesenchymal transition. ADAM33 is a disintegrin and metalloprotease domain-containing protein, which may be related to lung fibrosis by exerting angiogenesis and remodeling of the lung. Thus, we evaluated the association of single-nucleotide polymorphisms (SNPs) of ADAM33 with the risk of IPF.

Methods

A total of 237 patients with IPF and 183 healthy subjects participated in the present study. Nine polymorphisms were selected. Genotyping was performed by single-base extension. Polymorphisms and haplotypes were analyzed for associations with the risk of IPF using multiple logistic regression models controlling for age, gender, and smoking status as covariates.

Results

All SNPs were in Hardy-Weinberg equilibrium. The minor allele frequency (MAF) of rs628977G>A in intron 21 was significantly lower in subjects with surgical IPF than in normal controls in the recessive model [33.2 vs. 38.0 %, p = 0.02, OR = 0.40 (0.19–0.84)]. When the subjects with clinical IPF were included, the difference in MAF persisted with a p value of 0.03 [OR = 0.50 (0.27–0.94)].

Conclusions

ADAM33 rs628977G>A was marginally associated with a decreased risk of IPF in a recessive model.

Keywords

ADAM33 ProteinSingle nucleotide polymorphismsGenotypeIdiopathic pulmonary fibrosis

Copyright information

© Springer Science+Business Media New York 2014