Lung

, Volume 192, Issue 2, pp 243–249

Association of Depression with Disease Severity in Patients with Chronic Obstructive Pulmonary Disease

Authors

  • Ki Uk Kim
    • Department of Internal MedicinePusan National University School of Medicine
    • Medical Research InstitutePusan National University Hospital
    • Department of Internal MedicinePusan National University School of Medicine
    • Medical Research InstitutePusan National University Hospital
  • Hee Young Jung
    • Department of NursingPusan National University College of Nursing
  • Jong-Joon Ahn
    • Department of Internal MedicineUniversity of Ulsan College of Medicine
  • Eunsoo Moon
    • Department of PsychiatryPusan National University Hospital
  • Yun Seong Kim
    • Department of Internal MedicinePusan National University School of Medicine
    • Medical Research InstitutePusan National University Hospital
  • Min Ki Lee
    • Department of Internal MedicinePusan National University School of Medicine
    • Medical Research InstitutePusan National University Hospital
  • Haejung Lee
    • Department of NursingPusan National University College of Nursing
Article

DOI: 10.1007/s00408-013-9547-4

Cite this article as:
Kim, K.U., Park, H., Jung, H.Y. et al. Lung (2014) 192: 243. doi:10.1007/s00408-013-9547-4

Abstract

Purpose

Patients with chronic obstructive pulmonary disease (COPD), which is predicted to be the third most common cause of death worldwide by 2020, often suffer from depression, one of the most common and modifiable comorbidities of COPD. This study assessed the prevalence of depression in patients with COPD and the association of depression with disease severity.

Methods

This was a multicenter, prospective cross-sectional study of 245 patients with stable COPD. Disease severity was assessed using two scales: the global initiative for chronic obstructive lung disease (GOLD) stage and BODE index. Depression was measured using the Centers for Epidemiologic Studies Depression (CES-D) scales. Data were analyzed using descriptive statistics, Spearman correlation, and multivariate logistic regression.

Results

Depression defined as a CES-D score of 24 and higher was observed in 17.6 % of patients with COPD. The prevalence of depression increased with disease severity based on the BODE quartile (r = 0.16; P = 0.014). By contrast, no difference was observed in the prevalence of depression among the severity groups using the GOLD staging system (r = − 0.01; P = 0.898). Elementary school graduates were more likely to experience depression than graduates of high school and above [odds ratio (OR) = 3.67; 95 % confidence interval (CI) 1.37–9.85] and patients in BODE quartile II were more likely to experience depression than those with BODE quartile I (OR = 2.5; 95 % CI  1.04–6.06).

Conclusions

Depression was associated with disease severity according to the BODE quartile in patients with COPD. BODE quartile II was a significant predictor of depression. Screening patients with a high risk of depression and proactive intervention for those patients are needed.

Keywords

AirflowDepressionDyspneaExerciseObstruction

Copyright information

© Springer Science+Business Media New York 2014