, Volume 192, Issue 1, pp 33–38

Cough in Asthma Is due to Eosinophilic Airway Inflammation: A Pro/Con Debate

  • Akio Niimi
  • Christopher E. Brightling
  • Peter V. Dicpinigaitis

DOI: 10.1007/s00408-013-9543-8

Cite this article as:
Niimi, A., Brightling, C.E. & Dicpinigaitis, P.V. Lung (2014) 192: 33. doi:10.1007/s00408-013-9543-8


Multiple prospective studies have demonstrated that asthma is among the most common etiologies of chronic cough, along with upper-airway cough syndrome (formerly known as postnasal drip syndrome) and gastroesophageal reflux disease. More recently, the entity of nonasthmatic eosinophilic bronchitis has been appreciated as a significant cause of chronic cough worldwide. Chronic cough associated with both of these conditions typically responds well to therapy with systemic or inhaled corticosteroids, thus leading to a general assumption that the suppression of eosinophilic airway inflammation explains the improvement in cough. However, some recent studies challenge a causal relationship between eosinophilic airway inflammation and cough in asthmatics. The 4th American Cough Conference, held in New York in June 2013, provided an ideal forum for discussion and debate of this issue between two internationally recognized experts in the field of asthma and chronic cough.


Cough Asthma Eosinophil Inflammation 

Supplementary material

408_2013_9543_MOESM1_ESM.docx (16 kb)
Supplementary material 1 (DOCX 15 kb)

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Akio Niimi
    • 1
  • Christopher E. Brightling
    • 2
  • Peter V. Dicpinigaitis
    • 3
  1. 1.Division of Respiratory Medicine, Department of Medical Oncology and Immunology, University Graduate School of Medical SciencesNagoya City University HospitalNagoyaJapan
  2. 2.Department of Infection, Inflammation and Immunity, Institute for Lung HealthUniversity of LeicesterLeicesterUK
  3. 3.Department of MedicineAlbert Einstein College of Medicine and Montefiore Medical CenterBronxUSA

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