Lung

, Volume 190, Issue 2, pp 183–188

Airway IFN-γ Production During RSV Bronchiolitis is Associated with Eosinophilic Inflammation

Authors

  • Chang Keun Kim
    • Department of Pediatrics, Asthma and Allergy CenterInje University Sanggye Paik Hospital
  • Zak Callaway
    • Department of Pediatrics, Asthma and Allergy CenterInje University Sanggye Paik Hospital
    • School of Biological Sciences, College of Natural ScienceUniversity of Ulsan
  • Young Yull Koh
    • Department of PediatricsSeoul National University Hospital
  • Soo-Hee Kim
    • Department of Pediatrics, Asthma and Allergy CenterInje University Sanggye Paik Hospital
    • Institute for Clinical ResearchMie National Hospital
Article

DOI: 10.1007/s00408-011-9349-5

Cite this article as:
Kim, C.K., Callaway, Z., Koh, Y.Y. et al. Lung (2012) 190: 183. doi:10.1007/s00408-011-9349-5

Abstract

Study Objective

This study was designed to investigate the possible role of IFN-γ in eosinophil degranulation that occurs during respiratory syncytial virus (RSV) bronchiolitis.

Methods

Sixty-seven infants, 2–24 months old and hospitalized with their first episode of acute RSV bronchiolitis, were selected for this study. Eosinophil-active cytokine and chemokine profiles in nasal lavage supernatants taken within the first 48 h of admission were determined by a multiplex bead array system (Luminex). Comparisons were made with control (Control group) subjects (n = 20).

Results

Nasal IFN-γ levels were significantly higher (P < 0.0001) in RSV bronchiolitis (median = 4.4 pg/ml) infants compared to controls (0.0 pg/ml). IFN-γ levels correlated significantly with the levels of nasal eotaxin (r = 0.566, P < 0.0001), RANTES (r = 0.627, P < 0.0001), GM-CSF (r = 0.849, P < 0.0001), and EDN (r = 0.693, P < 0.001). Nasal interleukin (IL)-4, IL-5, and IL-13 were below sensitivity levels in most RSV bronchiolitis and control subjects.

Conclusion

These results suggest that IFN-γ may play an important role in eosinophilic inflammation in RSV bronchiolitis.

Keywords

Bronchiolitis Eosinophil Eosinophil-derived neurotoxin Interferon-γ Respiratory syncytial virus

Copyright information

© Springer Science+Business Media, LLC 2011