Article

Lung

, 189:377

First online:

Pulmonary Hypertension in a Stable Community-Based COPD Population

  • Vadim FayngershAffiliated withDivision of Pulmonary, Sleep and Critical Care Medicine, The Memorial Hospital of Rhode IslandDivision of Pulmonary, Sleep and Critical Care Medicine, The Alpert Medical School of Brown University
  • , Fotios DrakopanagiotakisAffiliated withDivision of Pulmonary, Sleep and Critical Care Medicine, Rhode Island Hospital
  • , F. Dennis McCoolAffiliated withDivision of Pulmonary, Sleep and Critical Care Medicine, The Memorial Hospital of Rhode IslandDivision of Pulmonary, Sleep and Critical Care Medicine, The Alpert Medical School of Brown University
  • , James R. KlingerAffiliated withDivision of Pulmonary, Sleep and Critical Care Medicine, Rhode Island HospitalDivision of Pulmonary, Sleep and Critical Care Medicine, The Alpert Medical School of Brown University Email author 

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Abstract

Study Objectives

The etiology and prevalence of pulmonary hypertension (PH) in patients with stable chronic obstructive pulmonary disease (COPD) is uncertain. This study was done to determine the prevalence of PH in stable COPD outpatients and to evaluate the relationship between PH and indices of pulmonary function.

Design

The study was a retrospective review of outpatients with COPD and PH defined as a history of cigarette smoking, pulmonary function tests (PFTs) that met GOLD criteria for airway obstruction, an echocardiogram within 6 months of PFTs, and a left ventricular ejection fraction (LVEF) >55%. Of the 159 individuals who met all inclusion criteria, 105 had a sufficient tricuspid regurgitant jet to measure systolic pulmonary artery pressure (sPAP). PH was defined as sPAP ≥36 mmHg.

Measurements and Results

The prevalence of PH was 60% (63/105) in the study group. The mean sPAP in patients with PH was 45 ± 6 mmHg. COPD patients with PH were older (71.1 ± 11.8 vs. 63.7 ± 10.2 years, P = 0.001), had lower FEV1% predicted (51.8 ± 18.8 vs. 62.7 ± 20.5%, P = 0.006), a higher RV/TLC (0.55 ± 0.10 vs. 0.48 ± 0.11, P = 0.001), and a lower % predicted DLCO (59.6 ± 19.5% vs. 71.9 ± 24.9%, P = 0.006). Only age (P < 0.002) and prebronchodilator FEV1% predicted (P < 0.006) predicted PH by logistic regression analysis. No differences were observed in gender, BMI, smoking status, pack years, total lung capacity (TLC), or residual volume (RV).

Conclusion

PH is common in COPD. Older individuals and those with more airway obstruction are at greater risk for developing PH.

Keywords

Pulmonary hypertension Chronic obstructive airway disease Transthoracic echocardiogram Pulmonary function tests