Lung

, Volume 189, Issue 4, pp 311–321

Diabetes, Impaired Glucose Tolerance, and Metabolic Biomarkers in Individuals with Normal Glucose Tolerance are Inversely Associated with Lung Function: The Jackson Heart Study

  • DeMarc A. Hickson
  • Cecil M. Burchfiel
  • Jiankang Liu
  • Marcy F. Petrini
  • Kimystian Harrison
  • Wendy B. White
  • Daniel F. Sarpong
Article

DOI: 10.1007/s00408-011-9296-1

Cite this article as:
Hickson, D.A., Burchfiel, C.M., Liu, J. et al. Lung (2011) 189: 311. doi:10.1007/s00408-011-9296-1

Abstract

The objectives of this study were to test the hypothesis that diabetes and impaired glucose tolerance (IGT), diabetes control and diabetes duration, and metabolic biomarkers in adults with normal glucose tolerance (NGT) are inversely associated with spirometry-measured lung function. We conducted a cross-sectional observational cohort study that included nonsmoking African American adults (n = 2,945; mean age = 52.5 ± 12.6 years; 69.2% female), who were free of cardiovascular disease, from the Jackson Heart Study. The interventions were diabetes, metabolic biomarkers and lung function. We measured the associations of glycemia with forced expiratory volume (FEV) in 1 s, FEV in 6 s, and vital capacity. Multivariable adjusted mean lung function values were lower among adults with diabetes and IGT (in women only, but not after adjustment for waist circumference) than adults with NGT. Among adults with diabetes, no associations were observed between lung function and diabetes control or duration. In women with NGT, lower lung function was consistently associated with higher glucose levels and less consistently with higher insulin levels and insulin resistance. Lower lung function was consistently associated with higher insulin levels and insulin resistance and less consistently associated with insulin and hemoglobin A1c in men with NGT. Overall, our findings generally support the hypothesis that diabetes, IGT, and increased levels of metabolic biomarkers in individuals with NGT are inversely associated with lung function in African Americans, independent of adiposity.

Keywords

Forced expiratory volume in 1 sInsulin resistanceSpirometryVital capacityImpaired glucose tolerance

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • DeMarc A. Hickson
    • 1
    • 2
  • Cecil M. Burchfiel
    • 3
  • Jiankang Liu
    • 2
  • Marcy F. Petrini
    • 2
  • Kimystian Harrison
    • 4
  • Wendy B. White
    • 4
  • Daniel F. Sarpong
    • 5
  1. 1.Jackson Heart StudyJackson State UniversityJacksonUSA
  2. 2.Department of MedicineUniversity of Mississippi Medical CenterJacksonUSA
  3. 3.Health Effects Laboratory DivisionNational Institute for Occupational Safety and HealthMorgantownUSA
  4. 4.Jackson Heart Study, Tougaloo CollegeTougalooUSA
  5. 5.Department of Epidemiology and BiostatisticsJackson State UniversityJacksonUSA