European Archives of Psychiatry and Clinical Neuroscience

, Volume 251, Issue 5, pp 205–210

Basic parameters of saccadic eye movements – differences between unmedicated schizophrenia and affective disorder patients

Authors

  • Richard Mahlberg
    • Psychiatrische Klinik und Poliklinik der Freien Universität Berlin, Eschenallee 3, 14050 Berlin, Germany, Tel.: +49-30/84 45 83 01, Fax: +49-30/84 45 83 50, E-Mail: mahlberg@zedat.fu-berlin.de
  • Bruno Steinacher
    • Psychiatrische Klinik und Poliklinik der Freien Universität Berlin, Eschenallee 3, 14050 Berlin, Germany, Tel.: +49-30/84 45 83 01, Fax: +49-30/84 45 83 50, E-Mail: mahlberg@zedat.fu-berlin.de
  • Arthur Mackert
    • Psychiatrische Klinik und Poliklinik der Freien Universität Berlin, Eschenallee 3, 14050 Berlin, Germany, Tel.: +49-30/84 45 83 01, Fax: +49-30/84 45 83 50, E-Mail: mahlberg@zedat.fu-berlin.de
  • Klaus-Malte Flechtner
    • Abteilung für Sozialpsychiatrie, Psychiatrische Klinik und Poliklinik der Freien Universität Berlin
ORIGINAL PAPER

DOI: 10.1007/s004060170028

Cite this article as:
Mahlberg, R., Steinacher, B., Mackert, A. et al. European Archives of Psychiatry and Clinical Neurosciences (2001) 251: 205. doi:10.1007/s004060170028

Abstract

Background Smooth pursuit eye movement (SPEM) dysfunctions are considered a biological marker for schizophrenia and have been studied widely. In contrast, saccadic eye movements have received less attention, although disturbances have been described previously. Basic neurophysiologic parameters of saccades in schizophrenics, especially in unmedicated patients, have not been studied extensively. Methods Saccadic eye movements of 38 unmedicated schizophrenic patients, 32 patients with major depression and 42 non-psychiatric controls were examined using high-resolution infrared oculography. Two large-amplitude saccadic tasks were presented. The groups were compared on peak velocity, reaction time and accuracy. Results Peak velocity was significantly increased in schizophrenic patients. Depressive patients had a significantly longer reaction time. Both patient groups needed more corrective saccades to reach the target than controls. Conclusions Peak velocity distinguishes unmedicated schizophrenic patients from depressive patients and normal controls. This could be explained by deficits of the prefrontal cortex in the inhibitory control of saccades. Our findings suggest that schizophrenia affects not only SPEM but also saccadic eye movements.

Key words Eye movementsSaccadesSchizophreniaPeak velocityBiological marker

Copyright information

© Steinkopff Verlag 2001