Early onset of lithium prophylaxis as a predictor of good long-term outcome
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- Franchini, L., Zanardi, R., Smeraldi, E. et al. European Archives of Psychiatry and Clinical Neurosciences (1999) 249: 227. doi:10.1007/s004060050091
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The recurrence rates during lithium preventive treatment were investigated in a sample of 270 Mood Disorder subjects subdivided according to their onset time for lithium prophylaxis as very early (within 5 years from the onset of illness), early (6–10 years), late (11–20 years) and very late (more than 21 years). 131 subjects of the sample followed for 4 years prolonged the observation for a further period of 8 years. Results indicated that beginning lithium therapy within the first ten years of illness predicts better preventive outcomes than beginning prophylaxis later, both in major depression, recurrent and bipolar patients.