Early onset of lithium prophylaxis as a predictor of good long-term outcome

  • L. Franchini
  • R. Zanardi
  • E. Smeraldi
  • M. Gasperini
Original paper

DOI: 10.1007/s004060050091

Cite this article as:
Franchini, L., Zanardi, R., Smeraldi, E. et al. European Archives of Psychiatry and Clinical Neurosciences (1999) 249: 227. doi:10.1007/s004060050091

Abstract

The recurrence rates during lithium preventive treatment were investigated in a sample of 270 Mood Disorder subjects subdivided according to their onset time for lithium prophylaxis as very early (within 5 years from the onset of illness), early (6–10 years), late (11–20 years) and very late (more than 21 years). 131 subjects of the sample followed for 4 years prolonged the observation for a further period of 8 years. Results indicated that beginning lithium therapy within the first ten years of illness predicts better preventive outcomes than beginning prophylaxis later, both in major depression, recurrent and bipolar patients.

Key words Prophylactic treatment Lithium salts Recurrence index 

Copyright information

© Steinkopff Verlag 1999

Authors and Affiliations

  • L. Franchini
    • 1
  • R. Zanardi
    • 1
  • E. Smeraldi
    • 1
  • M. Gasperini
    • 1
  1. 1.Istituto Scientifico H. San Raffaele, Department of Neuropsychiatric Sciences, University of Milan, Via Luigi Prinetti, 29, 20127 Milan, Italy e-mail: centro.affettivi@hsr.itIT

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