European Archives of Psychiatry and Clinical Neuroscience

, Volume 248, Issue 6, pp 296–300

Antidepressant-associated maniform states in acute treatment of patients with bipolar-I depression

Authors

  • R. Bottlender
    • Psychiatrische Klinik der Ludwig-Maximilians-Universität, Nussbaumstrasse 7, D-80336 Munich, Germany e-mail: bottlend@psy.med.uni-muenchen.de, Fax: +49-89-5160 4749
  • Daniel Rudolf
    • Psychiatrische Klinik der Ludwig-Maximilians-Universität, Nussbaumstrasse 7, D-80336 Munich, Germany e-mail: bottlend@psy.med.uni-muenchen.de, Fax: +49-89-5160 4749
  • Anton Strauss
    • Psychiatrische Klinik der Ludwig-Maximilians-Universität, Nussbaumstrasse 7, D-80336 Munich, Germany e-mail: bottlend@psy.med.uni-muenchen.de, Fax: +49-89-5160 4749
  • Hans-Jürgen Möller
    • Psychiatrische Klinik der Ludwig-Maximilians-Universität, Nussbaumstrasse 7, D-80336 Munich, Germany e-mail: bottlend@psy.med.uni-muenchen.de, Fax: +49-89-5160 4749
Original paper

DOI: 10.1007/s004060050053

Cite this article as:
Bottlender, R., Rudolf, D., Strauss, A. et al. European Archives of Psychiatry and Clinical Neurosciences (1998) 248: 296. doi:10.1007/s004060050053

Abstract

Medical records of 158 patients with bipolar depression were analysed for the incidence of a switch from depression to maniform states (mania and hypomania). Relation to psychopharmacological treatment was investigated. Thirty-nine (25%) patients of the total sample had switched to a maniform state during the treatment period in the hospital. Among that group the phenomenon occurred in 23 patients (15%) as a hypomania and in 16 patients (10%) as a mania. Patients with a switch were significantly more often treated with tricyclic antidepressants (TCA) than patients without switch (79.5% vs 51.3%). Mood stabilising medication might reduce the risk for switching, especially in patients treated with TCA; however, it seems not totally sufficient, since 59% of the switched patients received mood stabilisers. The switch phenomenon was not associated with sociodemographic or clinical data.

Key words Bipolar-I depressionSwitchAntidepressantsMood stabiliser

Copyright information

© Springer-Verlag Berlin Heidelberg 1998