Susceptibility for schizophrenia is not influenced by a functional insertion/deletion variant in the promoter of the serotonin transporter gene

  • G. Stöber
  • Susanne Jatzke
  • Armin Heils
  • Gerd Jungkunz
  • Elisabeth Fuchs
  • Michael Knapp
  • Peter Riederer
  • Klaus-Peter Lesch
Original paper

DOI: 10.1007/s004060050022

Cite this article as:
Stöber, G., Jatzke, S., Heils, A. et al. European Archives of Psychiatry and Clinical Neurosciences (1998) 248: 82. doi:10.1007/s004060050022
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Abstract

A possible dysregulation of serotonergic neurotransmission has been implicated in the aetiology of schizophrenic psychoses. In the present study we analysed allelic and genotypic variations of a recently described functional polymorphic region in the promoter of the human serotonin transporter gene (5-HTTLPR) and a variable tandem repeat (VNTR) in intron 2 of the 5-HTT gene. We investigated 413 unrelated individuals, 180 schizophrenic patients and 233 blood donors as controls. With regard to the 5-HTTLPR, both the schizophrenic and the control group did not significantly differ between genotype frequencies (χ2, p = 0.920) and allele frequencies (χ2, p = 0.836). The odds ratio for subjects with schizophrenia who were homozygous for the short allele was 1.04 (95% CI 0.59–1.84). No evidence of allelic association to specific schizophrenia subtypes was found. The 5-HTT associated VNTR also showed no significant differences between either the allelic or the genotypic distributions. Haplotype analysis revealed a significant overall linkage disequilibrium at a level of p = 0.00004. Our findings indicate that both polymorphisms are unlikely to play a substantial role in the genetic predisposition to schizophrenic disorders.

Key words 5-HTTSerotonin transporterGenePromoterAllelic variationRepeat elementpolymorphismSchizophrenia

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • G. Stöber
    • 1
  • Susanne Jatzke
    • 1
  • Armin Heils
    • 1
  • Gerd Jungkunz
    • 2
  • Elisabeth Fuchs
    • 3
  • Michael Knapp
    • 4
  • Peter Riederer
    • 1
  • Klaus-Peter Lesch
    • 1
  1. 1.Department of Psychiatry, University of Würzburg, Füchsleinstrasse 15, D-97080 Würzburg, GermanyDE
  2. 2.Psychiatric State Hospital, D-97816 Lohr a.M., GermanyDE
  3. 3.Institute of Transfusion Medicine, University of Würzburg, Füchsleinstrasse 15, D-97080 Würzburg, GermanyDE
  4. 4.Institute for Medical Statistics, University of Bonn, D-53105 Bonn, GermanyDE