Increased brain-derived neurotrophic factor (BDNF) protein concentrations in mice lacking brain serotonin

  • Golo Kronenberg
  • Valentina Mosienko
  • Karen Gertz
  • Natalia Alenina
  • Rainer Hellweg
  • Friederike Klempin
Short Communication

DOI: 10.1007/s00406-015-0611-3

Cite this article as:
Kronenberg, G., Mosienko, V., Gertz, K. et al. Eur Arch Psychiatry Clin Neurosci (2016) 266: 281. doi:10.1007/s00406-015-0611-3

Abstract

The interplay between BDNF signaling and the serotonergic system remains incompletely understood. Using a highly sensitive enzyme-linked immunosorbent assay, we studied BDNF concentrations in hippocampus and cortex of two mouse models of altered serotonin signaling: tryptophan hydroxylase (Tph)2-deficient (Tph2/) mice lacking brain serotonin and serotonin transporter (SERT)-deficient (SERT−/−) mice lacking serotonin re-uptake. Surprisingly, hippocampal BDNF was significantly elevated in Tph2/ mice, whereas no significant changes were observed in SERT−/− mice. Furthermore, BDNF levels were increased in the prefrontal cortex of Tph2/ but not of SERT−/− mice. Our results emphasize the interaction between serotonin signaling and BDNF. Complete lack of brain serotonin induces BDNF expression.

Keywords

BDNF SERT TPH2 Serotonin Depression Antidepressant 

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Golo Kronenberg
    • 1
  • Valentina Mosienko
    • 2
    • 4
  • Karen Gertz
    • 3
  • Natalia Alenina
    • 2
  • Rainer Hellweg
    • 1
  • Friederike Klempin
    • 2
  1. 1.Department of Psychiatry and Psychotherapy, Campus Charité MitteCharité - University Medicine BerlinBerlinGermany
  2. 2.Research Team ‘Cardiovascular Hormones and Peptides’Max-Delbruck-Center for Molecular Medicine (MDC)BerlinGermany
  3. 3.Department of NeurologyCharité - University Medicine BerlinBerlinGermany
  4. 4.School of Physiology and PharmacologyUniversity of BristolBristolUK

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