Antipsychotic-induced parkinsonism is associated with working memory deficits in schizophrenia-spectrum disorders

Original Paper

DOI: 10.1007/s00406-014-0511-y

Cite this article as:
Potvin, S., Aubin, G. & Stip, E. Eur Arch Psychiatry Clin Neurosci (2015) 265: 147. doi:10.1007/s00406-014-0511-y


In view of the significant cognitive deficits in schizophrenia and their impact on patients’ social and occupational functioning, and considering that the influence potential influence of antipsychotic-induced extrapyramidal symptoms on cognition in schizophrenia remains poorly understood, the current study sought to identify the clinical, socio-demographic and neurologic predictors of the cognitive performance of schizophrenia patients. Eighty-two schizophrenia-spectrum (DSM-IV criteria) outpatients were recruited. Psychiatric symptoms were evaluated with the Positive And Negative Syndrome Scale and the Calgary Depression Scale for Schizophrenia. Extrapyramidal symptoms were evaluated with the Extrapyramidal Symptoms Rating Scale, while spatial working, planning abilities and visual paired associates learning were evaluated with the CAmbridge Neuropsychological Tests Automated Battery. The Stroop test was also administered. Multivariate hierarchic linear regression analyses were performed. We found that negative symptoms were associated with cognitive flexibility, planning, visual learning and working memory performance in schizophrenia. Age, sex, number of hospitalizations and antipsychotic type also emerged as significant predictors. More importantly, we found a significant association between antipsychotic-induced parkinsonism and working memory performance. The fact that negative symptoms and socio-demographic variables predicted cognitive performance in schizophrenia is consistent with the previous literature on the topic. The finding of an association between parkinsonism and working memory may have clinical implications, since working memory deficits are considered putative endophenotypes of schizophrenia and are known to impair patients’ social and occupational functioning. Our results will need to be replicated in longitudinal studies involving larger samples of patients.


Schizophrenia Parkinsonism Working memory Cognitive flexibility Negative symptoms 

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Stéphane Potvin
    • 1
    • 2
  • Ginette Aubin
    • 2
    • 3
  • Emmanuel Stip
    • 2
    • 3
  1. 1.Centre de recherche de lInstitut Universitaire en Santé Mentale de MontréalMontréalCanada
  2. 2.Department of Psychiatry, Faculty of MedicineUniversity of MontrealMontrealCanada
  3. 3.Centre de recherche du Centre Hospitalier de lUniversité de MontréalMontrealCanada

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