European Archives of Psychiatry and Clinical Neuroscience

, Volume 262, Issue 7, pp 625–634

Antisaccade performance in patients with obsessive–compulsive disorder and unaffected relatives: further evidence for impaired response inhibition as a candidate endophenotype

  • Leonhard Lennertz
  • Friederike Rampacher
  • Andrea Vogeley
  • Svenja Schulze-Rauschenbach
  • Ralf Pukrop
  • Stephan Ruhrmann
  • Joachim Klosterkötter
  • Wolfgang Maier
  • Peter Falkai
  • Michael Wagner
Original Paper

DOI: 10.1007/s00406-012-0311-1

Cite this article as:
Lennertz, L., Rampacher, F., Vogeley, A. et al. Eur Arch Psychiatry Clin Neurosci (2012) 262: 625. doi:10.1007/s00406-012-0311-1

Abstract

Cognitive dysfunctions such as inhibitory deficits and visuospatial abnormalities are often found in patients with obsessive–compulsive disorder (OCD). Recent findings in unaffected relatives indicate that response inhibition and other neuropsychological functions may also constitute endophenotypes of OCD. In the present study, 30 OCD patients, 30 first-degree relatives, and 30 healthy control subjects were assessed using a comprehensive neuropsychological test battery. A subsample of 21 subjects of each group also performed an antisaccade task. The samples were matched according to age, gender, education, and verbal intelligence. The OCD patients and the unaffected OCD relatives showed increased antisaccade error rates compared with the healthy control group (p = 0.003, p = 0.028, respectively). Significantly prolonged antisaccade latencies as compared to prosaccade latencies were only found in the OCD patients compared with the healthy control group (p = 0.019). Only OCD patients but not the unaffected OCD relatives were impaired with regard to visuospatial functions, problem-solving, and processing speed. Antisaccade errors did not correlate with severity of OCD or depressive symptoms. This study confirms inhibitory deficits, as indicated by increased antisaccade error rates, as a candidate endophenotype of OCD. In agreement with previous findings from imaging studies, our data suggest that functional abnormalities in frontostriatal and parietal cortical regions form part of the vulnerability for OCD.

Keywords

Obsessive–compulsive disorderEndophenotypeCognitionNeuropsychologyAntisaccadeUnaffected relativesResponse inhibition

Supplementary material

406_2012_311_MOESM1_ESM.doc (52 kb)
Supplementary material 1 (DOC 52 kb)

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Leonhard Lennertz
    • 1
  • Friederike Rampacher
    • 1
  • Andrea Vogeley
    • 1
  • Svenja Schulze-Rauschenbach
    • 1
  • Ralf Pukrop
    • 2
  • Stephan Ruhrmann
    • 2
  • Joachim Klosterkötter
    • 2
  • Wolfgang Maier
    • 1
  • Peter Falkai
    • 3
  • Michael Wagner
    • 1
  1. 1.Department of Psychiatry and PsychotherapyUniversity of BonnBonnGermany
  2. 2.Department of Psychiatry and PsychotherapyUniversity of CologneCologneGermany
  3. 3.Department of Psychiatry and PsychotherapyUniversity of GöttingenGöttingenGermany