European Archives of Psychiatry and Clinical Neuroscience

, Volume 262, Issue 1, pp 13–22

Executive summary of the report by the WPA section on pharmacopsychiatry on general and comparative efficacy and effectiveness of antidepressants in the acute treatment of depressive disorders

  • Thomas C. Baghai
  • Pierre Blier
  • David S. Baldwin
  • Michael Bauer
  • Guy M. Goodwin
  • Kostas N. Fountoulakis
  • Siegfried Kasper
  • Brian E. Leonard
  • Ulrik F. Malt
  • Dan J. Stein
  • Marcio Versiani
  • Hans-Jürgen Möller
Original Paper

DOI: 10.1007/s00406-011-0274-7

Cite this article as:
Baghai, T.C., Blier, P., Baldwin, D.S. et al. Eur Arch Psychiatry Clin Neurosci (2012) 262: 13. doi:10.1007/s00406-011-0274-7

Abstract

Current gold standard in the treatment of depression includes pharmacotherapeutic and psychotherapeutic strategies together with social support. Due to the actually discussed controversies concerning the differential efficacy of antidepressants, a contribution to a comprehensive clarification seems to be necessary to avert further deterioration and uncertainty from patients, relatives, and their treating psychiatrists and general practitioners. Both efficacy and clinical effectiveness of antidepressants in the treatment of depressive disorders can be confirmed. Clinically meaningful antidepressant treatment effects were confirmed in different types of studies. Methodological issues of randomized controlled studies, meta-analyses, and effectiveness studies will be discussed. Furthermore, actual data about the differential efficacy and effectiveness of antidepressants with distinct pharmacodynamic properties and about outcome differences in studies using antidepressants and/or psychotherapy are discussed. This is followed by a clinically oriented depiction—the differential clinical effectiveness of different pharmacodynamic modes of action of antidepressants in different subtypes of depressive disorders. It can be summarized that the spectrum of different antidepressant treatments has broadened during the last decades. The efficacy and clinical effectiveness of antidepressants is statistically significant and clinically relevant and proven repeatedly. For further optimizing antidepressant treatment plans, clearly structured treatment algorithms and the implementation of psychotherapy seem to be useful. A modern individualized antidepressant treatment in most cases is a well-tolerated and efficacious tool to minimize the negative impact of the otherwise devastating and life-threatening outcome of depressive disorders.

Keywords

Antidepressant treatmentsDepressionPharmacological treatmentsPsychotherapy

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Thomas C. Baghai
    • 1
    • 2
  • Pierre Blier
    • 3
  • David S. Baldwin
    • 4
  • Michael Bauer
    • 5
  • Guy M. Goodwin
    • 6
  • Kostas N. Fountoulakis
    • 7
  • Siegfried Kasper
    • 8
  • Brian E. Leonard
    • 9
  • Ulrik F. Malt
    • 10
  • Dan J. Stein
    • 11
  • Marcio Versiani
    • 12
  • Hans-Jürgen Möller
    • 1
  1. 1.Department of Psychiatry and PsychotherapyLudwig-Maximilian-University of MunichMunichGermany
  2. 2.Department of Psychiatry and PsychotherapyUniversity RegensburgRegensburgGermany
  3. 3.Department of PsychiatryUniversity of OttawaOttawaCanada
  4. 4.University Department of PsychiatryUniversity of SouthamptonSouthamptonUK
  5. 5.University Hospital Carl Gustav CarusDresdenGermany
  6. 6.University DepartmentWarneford HospitalOxfordUK
  7. 7.3rd Department of PsychiatryAristotle University of ThessalonikiThessalonikiGreece
  8. 8.Department of Psychiatry and PsychotherapyMedical University of ViennaViennaAustria
  9. 9.National University of IrelandGalwayIreland
  10. 10.Department of Neuropsychiatry and Psychosomatic Medicine, Oslo University HospitalUniversity of OsloOsloNorway
  11. 11.MRC Unit of Anxiety DisordersUniversity of StellenboschCape TownSouth Africa
  12. 12.Department of PsychiatryFederal University of Rio de JaneiroRio de JaneiroBrazil