European Archives of Psychiatry and Clinical Neuroscience

, Volume 260, Supplement 2, pp 90–94

Intervention in at-risk states for developing psychosis


    • Department of Psychiatry and PsychotherapyUniversity of Cologne
  • Frauke Schultze-Lutter
    • University Hospital of Child and Adolescent PsychiatryUniversity of Bern
  • Andreas Bechdolf
    • Department of Psychiatry and PsychotherapyUniversity of Cologne
  • Joachim Klosterkötter
    • Department of Psychiatry and PsychotherapyUniversity of Cologne

DOI: 10.1007/s00406-010-0139-5

Cite this article as:
Ruhrmann, S., Schultze-Lutter, F., Bechdolf, A. et al. Eur Arch Psychiatry Clin Neurosci (2010) 260: 90. doi:10.1007/s00406-010-0139-5


Indicated prevention is currently one of the most promising approaches to fight the individual and societal burden associated with psychosis and particularly schizophrenia. The number of studies is still limited, yet encouraging results have been reported from pharmacological and psychotherapeutic trials. Furthermore, it has become clear that persons characterized by the at-risk criteria are already ill and do not only need preventive intervention but also treatment. As is indicated by a recent study successfully using omega-3 fatty acids for both purposes, it may be promising to develop and investigate interventions especially for the at-risk state, independent of their effectiveness in manifest disease states. An overview on the current findings and ongoing research in this area is provided.


Prevention of psychosisUltra-high riskProdromeBasic symptomsEarly intervention

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© Springer-Verlag 2010