European Archives of Psychiatry and Clinical Neuroscience

, Volume 260, Issue 4, pp 351–358

Psychopathological correlates of the entorhinal cortical shape in schizophrenia

Authors

    • Department of Psychiatry and PsychotherapyFriedrich-Schiller-University Jena
  • Kathrin Koch
    • Department of Psychiatry and PsychotherapyFriedrich-Schiller-University Jena
  • Gerd Wagner
    • Department of Psychiatry and PsychotherapyFriedrich-Schiller-University Jena
  • Martin Roebel
    • Department of Psychiatry and PsychotherapyFriedrich-Schiller-University Jena
  • Claudia Schachtzabel
    • Department of Psychiatry and PsychotherapyFriedrich-Schiller-University Jena
  • Igor Nenadic
    • Department of Psychiatry and PsychotherapyFriedrich-Schiller-University Jena
  • Carsten Albrecht
    • Institute of Computer EngineeringUniversity of Lübeck
  • Jürgen R. Reichenbach
    • Medical Physics Group, Institute for Diagnostic and Interventional RadiologyFriedrich-Schiller-University Jena
  • Heinrich Sauer
    • Department of Psychiatry and PsychotherapyFriedrich-Schiller-University Jena
  • Ralf G. M. Schlösser
    • Department of Psychiatry and PsychotherapyFriedrich-Schiller-University Jena
Original Paper

DOI: 10.1007/s00406-009-0083-4

Cite this article as:
Schultz, C.C., Koch, K., Wagner, G. et al. Eur Arch Psychiatry Clin Neurosci (2010) 260: 351. doi:10.1007/s00406-009-0083-4

Abstract

Animal experiments have shown that early developmental lesions of the entorhinal cortex lead, after a prolonged interval, to an enhanced mesolimbic dopamine release and an increased locomotor activity in rats. Hence, disturbed shape of the entorhinal cortex might indicate maturational abnormalities relevant for psychotic symptoms in schizophrenia. We used an automated surface-based MRI method to perform a region of interest analysis of entorhinal cortical surface area, folding and thickness in 59 patients with schizophrenia and 59 healthy controls. We postulated the entorhinal cortical surface area, folding index, and thickness to be significantly smaller in patients with schizophrenia. Additionally, we expected the complexity of the entorhinal cortical shape to be associated with psychotic symptoms in schizophrenia. Our ROI analysis showed a significant thinner left entorhinal cortex. In addition, our data demonstrate a positive correlation between left entorhinal cortical surface area and folding index and severity of psychotic symptoms. In conclusion, we present new evidence for the involvement of the entorhinal cortex in the pathogenesis of schizophrenia. As cortical folding is a stable neuroanatomical parameter terminated in early neonatal stages, our data give reason to assume that the vulnerability to develop psychotic symptoms might be manifest at an early level of brain maturation.

Keywords

SchizophreniaPsychotic symptomsEntorhinal cortexCortical surface areaCortical foldingCortical thickness

Copyright information

© Springer-Verlag 2009