Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia

  • Daniel Martins-de-Souza
  • Wagner F. Gattaz
  • Andrea Schmitt
  • Christiane Rewerts
  • Giuseppina Maccarrone
  • Emmanuel Dias-Neto
  • Christoph W. Turck
ORIGINAL PAPER

DOI: 10.1007/s00406-008-0847-2

Cite this article as:
Martins-de-Souza, D., Gattaz, W.F., Schmitt, A. et al. Eur Arch Psychiatry Clin Neurosci (2009) 259: 151. doi:10.1007/s00406-008-0847-2

Abstract

Schizophrenia is a complex disease, likely to be caused by a combination of serial alterations in a number of genes and environmental factors. The dorsolateral prefrontal cortex (Brodmann's Area 46) is involved in schizophrenia and executes high-level functions such as working memory, differentiation of conflicting thoughts, determination of right and wrong concepts and attitudes, correct social behavior and personality expression. Global proteomic analysis of post-mortem dorsolateral prefrontal cortex samples from schizophrenia patients and non-schizophrenic individuals was performed using stable isotope labeling and shotgun proteomics. The analysis resulted in the identification of 1,261 proteins, 84 of which showed statistically significant differential expression, reinforcing previous data supporting the involvement of the immune system, calcium homeostasis, cytoskeleton assembly, and energy metabolism in schizophrenia. In addition a number of new potential markers were found that may contribute to the understanding of the pathogenesis of this complex disease.

Keywords

schizophreniaproteomicsshotgunprefrontal cortexbiomarkers

Copyright information

© Steinkopff Verlag Darmstadt 2009

Authors and Affiliations

  • Daniel Martins-de-Souza
    • 1
    • 2
  • Wagner F. Gattaz
    • 1
  • Andrea Schmitt
    • 3
    • 4
  • Christiane Rewerts
    • 2
  • Giuseppina Maccarrone
    • 2
  • Emmanuel Dias-Neto
    • 1
    • 5
  • Christoph W. Turck
    • 2
  1. 1.Laboratório de NeurociênciasInstituto de Psiquiatria-Faculdade de Medicina-Universidade de São PauloSão PauloBrazil
  2. 2.Max Planck Institute of PsychiatryMunichGermany
  3. 3.Department of PsychiatryUniversity of GoettingenGoettingenGermany
  4. 4.Central Institute of Mental Health, J5MannheimGermany
  5. 5.University of Texas, MD Anderson Cancer CenterHoustonUSA