Neuregulin 1 ICE-single nucleotide polymorphism in first episode schizophrenia correlates with cerebral activation in fronto-temporal areas

  • Tilo Kircher
  • Renate Thienel
  • Michael Wagner
  • Martina Reske
  • Ute Habel
  • Thilo Kellermann
  • Ingo Frommann
  • Sibylle Schwab
  • Wolfgang Wölwer
  • Martina von Wilmsdorf
  • Dieter F. Braus
  • Andrea Schmitt
  • Alexander Rapp
  • Tony Stöcker
  • N. Jon Shah
  • Fritz A. Henn
  • Heinrich Sauer
  • Wolfgang Gaebel
  • Wolfgang Maier
  • Frank Schneider
ORIGINAL PAPER

DOI: 10.1007/s00406-008-0837-4

Cite this article as:
Kircher, T., Thienel, R., Wagner, M. et al. Eur Arch Psychiatry Clin Neurosci (2009) 259: 72. doi:10.1007/s00406-008-0837-4

Abstract

The Neuregulin (NRG1) gene has been associated with schizophrenia, but its functional implications are largely unknown. Our aim was to assess differential brain activation between patients carrying an at-risk allele on the Neuregulin 1 gene and patients without this genetic risk. Neural signal changes between 14 first episode schizophrenia patients with the at risk allele (SNP8NRG221533) from the Icelandic core haplotype and 14 without were measured with fMRI during a working memory task. Patients without the at risk allele showed greater activations (P < 0.05; corrected) in the left hippocampus, precuneus and cerebellum, as well as the right anterior cingulate. Brain regions previously associated with the pathology of Schizophrenia are differentially affected in those with a genetic at risk status in the NRG1 gene. Heterogeneity of structural and functional measures within patients characterized by clinical phenotypes may be in part due to this genetic variation.

Keywords

neuregulinschizophreniafunctional endophenotypeFMRI

Copyright information

© Steinkopff Verlag Darmstadt 2008

Authors and Affiliations

  • Tilo Kircher
    • 1
  • Renate Thienel
    • 1
  • Michael Wagner
    • 2
  • Martina Reske
    • 1
  • Ute Habel
    • 1
  • Thilo Kellermann
    • 1
  • Ingo Frommann
    • 2
  • Sibylle Schwab
    • 2
    • 3
    • 4
  • Wolfgang Wölwer
    • 9
  • Martina von Wilmsdorf
    • 9
  • Dieter F. Braus
    • 5
    • 10
  • Andrea Schmitt
    • 5
  • Alexander Rapp
    • 6
  • Tony Stöcker
    • 7
  • N. Jon Shah
    • 7
  • Fritz A. Henn
    • 5
  • Heinrich Sauer
    • 8
  • Wolfgang Gaebel
    • 9
  • Wolfgang Maier
    • 2
  • Frank Schneider
    • 1
  1. 1.Dept. of Psychiatry and Psychotherapy RWTH University of AachenAachenGermany
  2. 2.Dept. of Psychiatry and PsychotherapyUniversity of BonnBonnGermany
  3. 3.School of Psychiatry and Clinical NeurosciencesThe University of Western AustraliaPerthAustralia
  4. 4.Western Australian Institute for Medical ResearchPerthAustralia
  5. 5.Central Institute of Mental HealthMannheimGermany
  6. 6.Dept. of Psychiatry and PsychotherapyUniversity of TübingenTübingenGermany
  7. 7.Brain Imaging Center West (BICW), Research Center JülichJülichGermany
  8. 8.Dept. of Psychiatry and PsychotherapyUniversity of JenaJenaGermany
  9. 9.Dept. of Psychiatry and PsychotherapyUniversity of DüsseldorfDüsseldorfGermany
  10. 10.HSKWiesbadenGermany