European Archives of Psychiatry and Clinical Neuroscience

, Volume 258, Issue 3, pp 179–185

Mismatch negativity at acute and post-acute phases of first-episode schizophrenia

Authors

    • Department of Physiology, Istanbul Medical FacultyUniversity of Istanbul
  • H. Yasemin Keskin-Ergen
    • Department of Physiology, Istanbul Medical FacultyUniversity of Istanbul
  • Alp Üçok
    • Department of Psychiatry, Istanbul Medical FacultyUniversity of Istanbul
ORIGINAL PAPER

DOI: 10.1007/s00406-007-0772-9

Cite this article as:
Devrim-Üçok, M., Keskin-Ergen, H.Y. & Üçok, A. Eur Arch Psychiatry Clin Neurosc (2008) 258: 179. doi:10.1007/s00406-007-0772-9

Abstract

The objective of this study was to evaluate the mismatch negativity (MMN) in patients with first-episode schizophrenia at acute and post-acute phases in order to determine the contribution of trait and/or state features to MMN disturbances in schizophrenia. Subject groups comprised 30 patients with first-episode schizophrenia at the acute phase and 34 healthy controls. Ten patients were neuroleptic-naive during testing at the acute phase. Twenty-one patients were retested at the post-acute phase when their symptoms improved. All patients were taking antipsychotic medication at the post-acute retest session. MMN amplitude of the patients at acute phase did not differ from controls. However, MMN amplitude at post-acute phase was reduced compared to both controls and acute phase. Similar results were obtained when the analyses were confined to neuroleptic-naive patients. The sensory memory functions indexed by MMN seem to be unaffected at the onset of schizophrenia but deteriorated during the post-acute illness phase. MMN reduction at the post-acute phase might be emerged from antipsychotic medication.

Key words

schizophreniafirst-episodemismatch negativityacute phasepost-acute phaselongitudinal

Copyright information

© Springer 2007