[123I] ADAM brainstem binding correlates with the loudness dependence of auditory evoked potentials

  • Oliver Pogarell
  • Walter Koch
  • Nadine Schaaff
  • Gabriele Pöpperl
  • Christoph Mulert
  • Georg Juckel
  • Hans-Jürgen Möller
  • Ulrich Hegerl
  • Klaus Tatsch
ORIGINAL PAPER

DOI: 10.1007/s00406-007-0760-0

Cite this article as:
Pogarell, O., Koch, W., Schaaff, N. et al. Eur Arch Psychiatry Clin Neurosc (2007) 258: 40. doi:10.1007/s00406-007-0760-0
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Abstract

The in vivo assessment of brain serotonergic function might be of clinical relevance in neuropsychiatry. The loudness dependence of auditory evoked potentials (LD) has been proposed as an indirect indicator of cortical serotonergic activity, whereas single photon emission computed tomography (SPECT) and [123I]ADAM allow the selective assessment of brain serotonin transporters (SERT). The aim of this study was to investigate LD and SERT availability as independent variables of the brain serotonergic system in healthy volunteers. Fifteen (six male, nine female) subjects received both neurophysiological and imaging investigations. Evoked potentials were recorded following the application of acoustic stimuli with increasing intensities; the LD was analyzed using dipole source analysis. SPECT was performed four hours after injection of 137 ± 11.4 MBq [123I]ADAM. As a measure of SERT availability specific ADAM brainstem binding was used. LD correlated significantly with SERT availability (Pearson’s correlations: rho = −0.57, p < 0.05). The correlations remained significant after controlling for the effects of age or gender (partial correlations: rho = −0.60, p < 0.05) but were pronounced in the female group (rho = −0.83, p < 0.01). Associations between LD and SERT availability contribute to the understanding of the central serotonergic system and further validate the use of neurophysiological approaches as indirect measures of neurochemical brain activity.

Key words

serotonin transporterSERTsingle photon emission computed tomographySPECT[123I] ADAMauditory evoked potentialsloudness dependence

Copyright information

© Springer 2008

Authors and Affiliations

  • Oliver Pogarell
    • 1
    • 5
  • Walter Koch
    • 2
  • Nadine Schaaff
    • 1
  • Gabriele Pöpperl
    • 2
  • Christoph Mulert
    • 1
  • Georg Juckel
    • 1
    • 3
  • Hans-Jürgen Möller
    • 1
  • Ulrich Hegerl
    • 1
    • 4
  • Klaus Tatsch
    • 2
  1. 1.Dept. of PsychiatryLudwig-Maximilians-UniversityMunichGermany
  2. 2.Dept. of Nuclear MedicineLudwig-Maximilians-UniversityMunichGermany
  3. 3.Westphalian Center Bochum, Dept. of PsychiatryRuhr-UniversityBochumGermany
  4. 4.Dept. of PsychiatryUniversity of LeipzigLeipzigGermany
  5. 5.Dept. of PsychiatryLudwig-Maximilians-University of MunichMunichGermany