ORIGINAL PAPER

European Archives of Psychiatry and Clinical Neuroscience

, Volume 256, Issue 4, pp 236-239

First online:

Regional cerebral blood flow change in a case of Alzheimer's disease with musical hallucinations

  • T. MoriAffiliated withDepartment of Neuropsychiatry, Ehime University School of Medicine, Toon city
  • , M. IkedaAffiliated withDepartment of Neuropsychiatry, Ehime University School of Medicine, Toon city Email author 
  • , R. FukuharaAffiliated withDepartment of Neuropsychiatry, Ehime University School of Medicine, Toon city
  • , Y. SugawaraAffiliated withDepartment of Radiology, Ehime University School of Medicine, Toon city
  • , S. NakataAffiliated withDepartment of Radiology, Ehime University School of Medicine, Toon city
  • , N. MatsumotoAffiliated withDepartment of Neuropsychiatry, Ehime University School of Medicine, Toon city
  • , P. J. NestorAffiliated withUniversity of Cambridge Neurology Unit, Addenbrooke's Hospital
  • , H. TanabeAffiliated withDepartment of Neuropsychiatry, Ehime University School of Medicine, Toon city

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Abstract

We examined alteration of regional cerebral blood flow (rCBF) in a case of Alzheimer's disease (AD) patient with musical hallucination. To detect regions related to musical hallucination, single–photon emission computed tomography (SPECT) imaging of the patient and nine sex, age, and cognitive functionmatched AD patients without delusions and hallucinations were compared using statistical parametric mapping 99 (SPM99). In comparison with controls, the patient had increased rCBF in left temporal regions and left angular gyrus. This profile could be relevant to the neuroanatomical basis of musical hallucinations.

Key words

single–photon emission computed tomography regional cerebral blood flow musical hallucination Alzheimer's disease superior temporal gyrus