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Safety of intralesional cidofovir in patients with recurrent respiratory papillomatosis: an international retrospective study on 635 RRP patients

  • Laryngology
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Abstract

Intralesional use of cidofovir (Vistide®) has been one of the mainstays of adjuvant therapy in patients with recurrent respiratory papillomatosis (RRP) since 1998. In 2011, a communication provided by the producer of cidofovir addressed very serious side effects concerning its off-label use. As this was a general warning, it was inconclusive whether this would account for its use in RRP. The aim of this study is to determine whether nephrotoxic, neutropenic, or oncogenic side effects have occurred after intralesional use of cidofovir in patients with RRP. Update of recent developments in RRP, a multicentre questionnaire and a multicentre retrospective chart review. Sixteen hospitals from eleven countries worldwide submitted records of 635 RRP patients, of whom 275 were treated with cidofovir. RRP patients received a median of three intralesional injections (interquartile range 2–6). There were no statistical differences in occurrence of neutropenia or renal dysfunction before and after cidofovir. There was no statistical difference in occurrence of upper airway and tracheal malignancies between the cidofovir and the non-cidofovir group. In this retrospective patient chart review, no clinical evidence was found for more long-term nephrotoxicity, neutropenia or laryngeal malignancies after the administration of intralesional cidofovir in RRP patients.

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Authors and Affiliations

  1. Department of Otorhinolaryngology Head and Neck Surgery, University of Groningen, University Medical Center Groningen, P.O. box 30001, 9700, RB, Groningen, The Netherlands

    R. E. A. Tjon Pian Gi & F. G. Dikkers

  2. Department of Otorhinolaryngology Head and Neck Surgery, Helsinki University Hospital, Helsinki, Finland

    T. Ilmarinen & L. M. Aaltonen

  3. Department of Epidemiology University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

    E. R. van den Heuvel

  4. Ear-Nose-Throat Department, Regionshospitalet Viborg, Viborg, Denmark

    J. Andersen

  5. Department of Otorhinolaryngology/Head and Neck Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands

    J. W. Brunings

  6. ENT Department, “Iuliu Hatieganu”, University of Medicine and Pharmacy, Cluj-Napoca Emergency County Hospital, Cluj-Napoca, Romania

    M. Chirila

  7. Department of Otorhinolaryngology, University of Leipzig, Leipzig, Germany

    A. Dietz & F. Lindner

  8. Department of Otorhinolaryngology, Hospital Gral de Catalunya Sant Cugat del Vallès, Barcelona, Spain

    F. Ferran Vilà

  9. Department of Otorhinolaryngology, Medical University of Graz, Graz, Austria

    G. Friedrich & M. Graupp

  10. Department of Otorhinolaryngology/Head and Neck Surgery, Erasmus University Rotterdam, Rotterdam, The Netherlands

    H. H. W. de Gier

  11. Department of Otorhinolaryngology, Greater Poland Cancer Centre, Poznan, Poland

    W. Golusinski

  12. 1st Department of Otorhinolaryngology, Hippocrateion General Hospital, University of Athens, Athens, Greece

    A. Hantzakos

  13. ENT Department, Hospital Infantil del Estado de Chihuahua, Chihuahua, Mexico

    R. Horcasitas

  14. Department of Otolaryngology, Poznan University of Medical Sciences, Poznan, Poland

    J. Jackowska & M. Wierzbicka

  15. Department of Otorhinolaryngology/Head and Neck Surgery, Klinikum-Stuttgart, Katharinenhospital, Stuttgart, Germany

    J. C. Koelmel & C. Sittel

  16. Department of Otorhinolaryngology, University Hospital of Louvain de Mont-Godinne, Yvoir, Belgium

    G. Lawson & M. Remacle

  17. Department of Hearing Speech and Voice Disorders, Innsbruck Medical University, Innsbruck, Austria

    V. Weichbold

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  1. R. E. A. Tjon Pian Gi
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  18. G. Lawson
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Corresponding author

Correspondence to R. E. A. Tjon Pian Gi.

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On behalf of the RRP study group of the ELS (European Laryngological Society).

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Tjon Pian Gi, R.E.A., Ilmarinen, T., van den Heuvel, E.R. et al. Safety of intralesional cidofovir in patients with recurrent respiratory papillomatosis: an international retrospective study on 635 RRP patients. Eur Arch Otorhinolaryngol 270, 1679–1687 (2013). https://doi.org/10.1007/s00405-013-2358-7

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