European Archives of Oto-Rhino-Laryngology

, Volume 270, Issue 2, pp 615–622

Quantitative assessment of the association between GSTM1 null genotype and laryngeal cancer risk

  • Hui Xiao
  • Minghua Li
  • Linli Tian
  • Bin Zha
  • Ming Liu
  • Hongchao Yao
Laryngology

DOI: 10.1007/s00405-012-2148-7

Cite this article as:
Xiao, H., Li, M., Tian, L. et al. Eur Arch Otorhinolaryngol (2013) 270: 615. doi:10.1007/s00405-012-2148-7

Abstract

Previous studies investigating the association between glutathione S-transferase M1 (GSTM1) null genotype and laryngeal cancer risk reported controversial results. Thus, a meta-analysis was performed to clarify the effect of GSTM1 null genotype on laryngeal cancer risk. A literature search was performed for all possible studies. We estimated summary odd ratio (OR) with its 95 % confidence interval (95 % CI) to assess the association. Subgroup analyses were performed by ethnicity or the sample size. 24 individual case–control studies involving a total of 2,809 laryngeal cancer cases and 4,478 controls were finally included into this meta-analysis. Meta-analyses of total 24 studies showed the GSTM1 null genotype was significantly associated with increased laryngeal cancer risk (random-effects OR = 1.44, 95 % CI 1.19–1.73, P < 0.001). Subgroup analyses by ethnicity showed that the GSTM1 null genotype was associated with increased laryngeal cancer risk in both Caucasians (fixed-effects OR = 1.17, 95 % CI 1.04–1.33, P = 0.012) and Asians (random-effects OR = 1.89, 95 % CI 1.28–2.77, P = 0.001). Also, subgroup analyses by sample size also further identified this association above. The cumulative meta-analyses showed a trend of more obvious association between GSTM1 null genotype and increased risk of laryngeal cancer as information accumulated by year. Meta-analysis of available data suggests that GSTM1 null genotype contributes to increased laryngeal cancer risk in both Caucasians and East Asians.

Keywords

Laryngeal cancerGene polymorphismGlutathione S-transferaseMeta-analysis

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Hui Xiao
    • 1
  • Minghua Li
    • 1
  • Linli Tian
    • 1
  • Bin Zha
    • 1
  • Ming Liu
    • 1
  • Hongchao Yao
    • 1
  1. 1.Department of Otolaryngology Head and Neck SurgeryThe Second Affiliated Hospital of Harbin Medical UniversityHarbinChina