European Archives of Oto-Rhino-Laryngology

, Volume 269, Issue 9, pp 2021–2026

Can vaccination against pneumococci prevent otitis media with effusion?

Authors

    • Otorhinolaryngolgy Department, Faculty of MedicineAin Shams University
  • Naema M. Ismail
    • Audiology Unit, Otorhinolaryngology Department, Faculty of MedicineAl-Azhar University
  • Salma B. Galal
    • WHO
  • Tamer S. Sobhy
    • Otorhinolaryngolgy Department, Faculty of MedicineAin Shams University
  • Amal A. Hegazy
    • Community and Industrial Medicine DepartmentAl-Azhar University
    • King Abdul Aziz University
Review Article

DOI: 10.1007/s00405-012-1975-x

Cite this article as:
El-Makhzangy, A.M.N., Ismail, N.M., Galal, S.B. et al. Eur Arch Otorhinolaryngol (2012) 269: 2021. doi:10.1007/s00405-012-1975-x

Abstract

The most common cause of hearing loss in early childhood is otitis media with effusion (OME). Prevention of OME in preschool children will improve quality of life. The authors aimed to determine, by the best available published evidence, whether vaccination against pneumococci effectively prevents OME. The study design was based on systematic review (SR) of randomized controlled trials (Level 1a evidence). The medical literature available through searching Medline database was reviewed using the following keywords “Otitis media with effusion,” “secretory otitis media,” or “glue ear,” and “vaccination” limiting the search to randomized controlled trials (RCTs) conducted on children (0–18 years), published in English, in the last 10 years. Results of effects of vaccination on prevention of OME from the included RCTs were utilized to conduct a meta-analysis to find out the preventive value of antipneumococcal vaccination. Three RCTs were identified conforming to the inclusion criteria. Meta-analysis of results showed no significant preventive advantage for antipneumococcal vaccination. Based on the results it was confirmed that neither primary nor secondary prevention by antipneumococcal vaccination has a beneficial impact on OME. More RCTs should be conducted to study the effect of vaccination on OME. Level of evidence: 1a, Systematic Review of Randomized Controlled Trials.

Keywords

Otitis media with effusionSecretory otitisGlue earPneumococcal vaccinationImmunization

Copyright information

© Springer-Verlag 2012