European Archives of Oto-Rhino-Laryngology

, Volume 269, Issue 3, pp 959–963

MRI-derived tumor thickness: an important predictor of outcome for T4a-staged tongue carcinoma

  • Wei-Lin Chen
  • Chin-Chuan Su
  • Chih-Ming Chen
  • Ming-Che Lee
  • Hui-Chuan Chen
  • Mu-Kuan Chen
Head and Neck

DOI: 10.1007/s00405-011-1685-9

Cite this article as:
Chen, WL., Su, CC., Chen, CM. et al. Eur Arch Otorhinolaryngol (2012) 269: 959. doi:10.1007/s00405-011-1685-9

Abstract

The objectives of this paper are to evaluate the heterogeneity of magnetic resonance imaging (MRI)-derived tumor thickness within tumors of the same T4a-staged tongue carcinoma and to elucidate the effects of tumor thickness on treatment outcomes. A sequential and prospectively maintained head and neck cancer database was retrospectively searched for newly diagnosed tongue carcinoma treated with surgery between 2003 and 2006. Fifty-eight patients with newly diagnosed T4a-staged tongue carcinoma were included in this study. Tumor thickness was obtained from preoperative magnetic resonance imaging. The mean MRI-derived tumor thickness was 22.29 mm. The patients with long tumor thickness (>26 mm) were associated with a significantly poor disease-specific survival (P = 0.015). The 2-year disease-specific survival rates were 72% in patients with short tumor thickness and only 27% in patients with long tumor thickness within the same T4a-staged disease. A substantial variation in MRI-derived tumor thickness was present within the same T4a-staged tongue carcinoma, and tumor thickness represented an important prognostic factor.

Keywords

T4a-stagedTNM stageTongue carcinomaTumor thicknessPrognosis

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Wei-Lin Chen
    • 1
  • Chin-Chuan Su
    • 1
  • Chih-Ming Chen
    • 1
  • Ming-Che Lee
    • 2
  • Hui-Chuan Chen
    • 3
  • Mu-Kuan Chen
    • 1
    • 4
    • 5
  1. 1.Department of Otorhinolaryngology, Head and Neck SurgeryChanghua Christian HospitalChanghuaTaiwan
  2. 2.Department of Medical ImagingChanghua Christian HospitalChanghuaTaiwan
  3. 3.Providence UniversityTaichungTaiwan
  4. 4.School of Medicine and Institute of MedicineChung Shan Medical UniversityTaichungTaiwan
  5. 5.Oral Cancer CenterChanghua Christian HospitalChanghuaTaiwan