European Archives of Oto-Rhino-Laryngology

, Volume 268, Issue 2, pp 165–179

Effects of tumour stage, comorbidity and therapy on survival of laryngeal cancer patients: a systematic review and a meta-analysis

  • Elisabeth Rudolph
  • Gerhard Dyckhoff
  • Heiko Becher
  • Andreas Dietz
  • Heribert Ramroth
Review Article

DOI: 10.1007/s00405-010-1395-8

Cite this article as:
Rudolph, E., Dyckhoff, G., Becher, H. et al. Eur Arch Otorhinolaryngol (2011) 268: 165. doi:10.1007/s00405-010-1395-8

Abstract

Laryngeal cancer is the second most common cancer of the respiratory tract with a relative 5-year survival over all tumour sites in the USA (61.6%; SEER 2009), which is much better than other head and neck cancers. The aim of this paper is to review and summarise data on the survival of laryngeal cancer patients. Literature search was conducted to identify articles in PubMed up to June 2009. Thirty studies with different study aims including sufficient information on survival of laryngeal cancer patients were identified. The 5-year overall survival ranged from 0 to 100%, depending on the T- and N-category, therapeutic approach and tumour location. The involvement of other factors such as genetics, nutrition and lifestyle habits remains uncertain. Our meta-analysis on a subgroup of published studies yielded an overall 5-year relative survival rate of 64.2% (95% confidence interval 63.7–64.7%). Different study aims and patient selection criteria prohibit general conclusions. However, this review may provide an actual picture of the complexity of factors influencing the survival of laryngeal cancer patients.

Keywords

Laryngeal cancer Survival Tumour stage Therapy Comorbidity 

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Elisabeth Rudolph
    • 1
  • Gerhard Dyckhoff
    • 2
  • Heiko Becher
    • 1
  • Andreas Dietz
    • 3
  • Heribert Ramroth
    • 1
  1. 1.Institute of Public HealthUniversity of HeidelbergHeidelbergGermany
  2. 2.Department of Otorhinolaryngology, Head and Neck SurgeryUniversity of HeidelbergHeidelbergGermany
  3. 3.Department of Otorhinolaryngology, Head and Neck SurgeryUniversity of LeipzigLeipzigGermany

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