European Archives of Oto-Rhino-Laryngology

, Volume 268, Issue 1, pp 5–16

Update of prognostic and predictive biomarkers in oropharyngeal squamous cell carcinoma: a review

Review Article

DOI: 10.1007/s00405-010-1369-x

Cite this article as:
Grimminger, C.M. & Danenberg, P.V. Eur Arch Otorhinolaryngol (2011) 268: 5. doi:10.1007/s00405-010-1369-x
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Abstract

Oropharyngeal squamous cell carcinomas (OSCC) constitute about 5% of all cancers in the western world and the incidence and mortality rates of this tumor have shown little improvement over the last 30 years. Molecular targeted therapy, a promising strategy for the treatment of OSCC and other cancers, requires the understanding of specific molecular events of carcinogenesis and the different pathological, partly interrelated pathways. Extended knowledge of the prognostic or predictive value of molecular biomarkers in oropharyngeal cancer is necessary to allow a better characterization and classification of the tumor, improve the appraisal of clinical outcome and help to specify individual multimodal therapy with increased efficiency. This work affords an updated summary regarding recent data about tissue biomarkers in patients with OSCC, based on the six essential hallmarks of cancer described by Hanahan and Weinberg (Cell 100(1):57–70, 2000) providing the characterization of a malignant cell.

Keywords

OSCC Predictive and prognostic biomarker Hallmarks of cancer HPV 

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  1. 1.Department of Biochemistry and Molecular BiologyUniversity of Southern CaliforniaLos AngelesUSA
  2. 2.Department of Otorhinolaryngology and Head and Neck SurgeryUniversity Hospital of CologneKölnGermany

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