European Archives of Oto-Rhino-Laryngology

, Volume 266, Issue 11, pp 1767–1773

Nasopharyngeal carcinoma in adolescents: a retrospective review of 42 patients

Authors

  • Said Afqir
    • Department of Medical OncologyNational Institute of Oncology
    • Department of Medical OncologyNational Institute of Oncology
  • Khaoula Alaoui
    • Department of Medical OncologyNational Institute of Oncology
  • Samir Ahid
    • Department of Medical StatisticsFaculty of Medicine
  • Jean-Pierre Lotz
    • Department of Medical OncologyHôpital Tenon
  • Elizabeth Horn
    • School of MedicineGeorge Washington University
  • Touria Bouhafa
    • Department of RadiotherapyNational Institute of Oncology
  • Redouane Abouqal
    • Department of Medical StatisticsFaculty of Medicine
  • Hassan Errihani
    • Department of Medical OncologyNational Institute of Oncology
Head and Neck

DOI: 10.1007/s00405-009-0911-1

Cite this article as:
Afqir, S., Ismaili, N., Alaoui, K. et al. Eur Arch Otorhinolaryngol (2009) 266: 1767. doi:10.1007/s00405-009-0911-1

Abstract

The aim of the present study was to evaluate the characteristics and outcome of adolescent patients with nasopharyngeal carcinoma (NPC) disease. The study concerned 46 pediatric NPC patients treated during the period 1999–2002 at the National Institute of Oncology, Rabat. The median age of the patients was 16 years. The male/female ratio was 2.8/1. Histologically, all patients had undifferentiated carcinoma. A total of 93% presented nodal metastasis. Four (9%) had distant metastasis. All patients received neoadjuvant multiagent chemotherapy containing cisplatin, followed by radiotherapy. Kaplan–Meier curves were used to evaluate prognostic factors. The log-rank test was used to evaluate the differences between the groups. While none of the patients had locoregional failure, nine patients (29%) developed distant metastasis. The disease-free survival and overall survival (OS) rate for the entire group were 73 and 41%, respectively. Responders to chemotherapy had superior OS (P < 0.001). We suggest that combined modality management using multi-agent chemotherapy and RT as an effective treatment of NPC disease which will achieve satisfactory locoregional control and OS of NPC pediatric patients. Response to chemotherapy was an important prognostic factor.

Keywords

Nasopharyngeal carcinomaChildren and adolescentsChemotherapyRadiotherapy

Copyright information

© Springer-Verlag 2009