European Archives of Oto-Rhino-Laryngology

, Volume 265, Issue 3, pp 377–380

Parotid localized Castleman’s disease and HHV-8 infection: a case report

Authors

  • Elisabetta Caselli
    • Section of Microbiology, Department of Experimental and Diagnostic MedicineUniversity of Ferrara
    • Otorhinolaryngology ClinicsUniversity of Ferrara
  • Roberto Di Carlo
    • Otorhinolaryngology ClinicsSt. Anna Hospital
  • Enrico Grandi
    • Section of Anatomy Histology and Pathological CitologyUniversity of Ferrara
  • Monica Galvan
    • Section of Microbiology, Department of Experimental and Diagnostic MedicineUniversity of Ferrara
  • Enzo Cassai
    • Section of Microbiology, Department of Experimental and Diagnostic MedicineUniversity of Ferrara
  • Antonio Pastore
    • Otorhinolaryngology ClinicsUniversity of Ferrara
Case Report

DOI: 10.1007/s00405-007-0453-3

Cite this article as:
Caselli, E., Padovani, D., Di Carlo, R. et al. Eur Arch Otorhinolaryngol (2008) 265: 377. doi:10.1007/s00405-007-0453-3

Abstract

Castleman’s disease (CD) is an unusual massive proliferation of lymphoid tissue distinct in two clinical forms, localized and multicentric. The multicentric form has been related to human herpesvirus 8 (HHV-8), especially in HIV-infected patients, whereas the localized form of CD is still unrelated to viral pathogens. We report a case of a HIV-negative 16-year-old male referred to our hospital with a 12-month history of a painless swelling in his right parotid region. A parotidectomy was performed, and histological analysis evidenced a localized CD. The search for HHV-8 revealed an active virus infection. The patient was commenced on corticosteroid therapy and a follow-up was performed every 6 months. The patient was commenced on corticosteroid therapy and there has been no recurrence after 24 months. The authors report a case of localized parotid CD in a patient with evidence of an active HHV-8 infection. The results of this study does for the first time suggest an association between HHV-8 and localized CD in HIV-negative subjects.

Keywords

Castleman’s diseaseParotid glandHuman herpesvirus-8Angiofollicular lymph node hyperplasiaViral infection

Copyright information

© Springer-Verlag 2007