Head and Neck

European Archives of Oto-Rhino-Laryngology

, Volume 264, Issue 7, pp 789-795

First online:

Carcinoma ex pleomorphic adenoma of the salivary gland: an immunohistochemical study

  • Saori MatsubayashiAffiliated withDepartment of Otolaryngology, Tokyo Women’s Medical University
  • , Toshio YoshiharaAffiliated withDepartment of Otolaryngology, Tokyo Women’s Medical University Email author 

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The proliferative activity of the tumor cells and the expression of tumor-associated genes and sex steroid hormone receptors were investigated immunohistochemically in ten cases of carcinoma ex pleomorphic adenoma (Ca-ex-PA) of the salivary glands. These were analyzed in benign and malignant components separately, and then were compared with ten cases of the other malignant tumors [adenocarcinomas, not otherwise specified (ACN) and salivary duct carcinomas (SDC)] and ten cases of pleomorphic adenomas (PA). The results obtained in this study were as follows: (1) malignant component of Ca-ex-PA showed a higher incidence of PCNA and Ki67 than benign component of Ca-ex-PA. A significant difference between benign component of Ca-ex-PA and PA was not observed. (2) A significant difference in the incidence of p53, c-erbB-2, EGFR overexpression was observed only between malignant component of Ca-ex-PA and benign component of Ca-ex-PA. (3) The incidence of PCNA, Ki67, p53, c-erbB-2 overexpression in malignant component of Ca-ex-PA showed the highest data among the four groups. These results suggest that Ca-ex-PA acquired the particular biological behavior in contrast to the other salivary neoplasms in the long-standing process while PA undergoes malignant transformation.


Salivary gland tumor Carcinoma ex pleomorphic adenoma Immunohistochemistry c-erbB-2 Androgen receptor