Rhinology

European Archives of Oto-Rhino-Laryngology

, Volume 264, Issue 4, pp 395-399

Polymorphisms in the IL-13 and IL-4 receptor alpha genes and allergic rhinitis

  • Jeong Joong KimAffiliated withDepartment of Anatomy, Wonkwang Institute of Medical Science, Wonkwang University School of Medicine
  • , Jung Youl MinAffiliated withDepartment of Anatomy, Wonkwang Institute of Medical Science, Wonkwang University School of Medicine
  • , Jae Hoon LeeAffiliated withDepartment of Otolaryngology, Wonkwang Institute of Medical Science, Wonkwang University School of Medicine Email author 

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Abstract

The IL-4 receptor (IL-4R) and IL-13 genes are candidate genes in atopic diseases. The IL-4Rα chain and IL-13 promoter polymorphisms are gain-of-function mutations associated with atopy. We tested whether polymorphisms in the IL-4Rα chain and the coding region of the IL-13 gene are associated with allergic rhinitis in a Korean population. Polymerase chain reaction-based assays for IL-4Rα Gln551Arg and IL-13 exon 4 G2044A were used for genotyping. There were no differences in the frequencies of the genotypes and alleles of IL-4Rα between the controls and patients. The frequency of the IL-13 exon 4 2044A allele was statistically different between the controls and patients. Our results suggest that the IL-13 exon 4 G2044A polymorphism confers susceptibility to the development of allergic rhinitis in Koreans, whereas the IL-4Rα Gln551Arg polymorphism is not related to allergic rhinitis.

Keywords

IL-4 receptor alpha IL-13 Allergic rhinitis Polymorphism