European Archives of Oto-Rhino-Laryngology

, Volume 260, Issue 9, pp 509–512

Adenosquamous carcinoma of the tongue in a 22-year-old female: report of a case with immunohistochemistry


    • Department of OtolaryngologySouth Infirmary Victoria Hospital
    • 17 Hampton Square
  • Jim Fitzgibbon
    • Department of PathologyMercy Hospital
  • Gary Lee
    • Department of PathologyMercy Hospital
  • Gerard O'Leary
    • Department of OtolaryngologySouth Infirmary Victoria Hospital
Head and Neck Oncology

DOI: 10.1007/s00405-003-0616-9

Cite this article as:
Sheahan, P., Fitzgibbon, J., Lee, G. et al. Eur Arch Otorhinolaryngol (2003) 260: 509. doi:10.1007/s00405-003-0616-9


Adenosquamous carcinoma is a very rare tumor that is characterized pathologically by the simultaneous presence of distinct areas of adenocarcinoma and squamous cell carcinoma. Only 15 cases in the oral cavity are reported in the literature, most occurring in middle-aged and elderly males. Pain is a commonly reported presenting symptom and may be related to the frequent presence of perineural invasion. Most cases have been treated surgically. However, early recurrence and death due to disease are common. We report an exceptional case occurring in a 22-year-old female. The tumor was associated with dysplasia of both minor salivary gland ductal epithelium and surface mucosal epithelium. Perineural invasion was also present. The patient was treated with combined surgery and radiotherapy and remained well for 9 months before developing locoregional recurrence and ultimately succumbing to the disease.


Adenosquamous carcinomaTongueOral cavity

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© Springer-Verlag is a part of Springer Science+Business Media 2003