Abstract
Objective
To assess the efficacy of short-course postpartum (6-h) magnesium sulfate therapy versus 24-h conventional magnesium sulfate therapy in severe preeclampsia.
Methods
Cases of severe preeclampsia were randomly allocated to group A (n = 76) and group B (n = 43). Group A and group B received magnesium sulfate loading dose (4 g) followed by infusion for 6 and 24 h postpartum (1 gm/h), respectively. Cases in both the groups were monitored closely after the initiation of therapy. t test and Chi-square test were used for data analysis.
Results
No occurrence of convulsions was noted in both group A and group B. The mean amount of magnesium sulfate used in the study group was 15.1 ± 5.4 g as against 42.3 ± 7.3 g in controls. The duration of Foley catheterization and monitoring was significantly less in group A (mean 11.3 ± 5.1 and 11.1 ± 4.9 h, respectively) as compared to group B (mean 38.3 ± 7.3 and 38.4 ± 7.2 h, respectively). The mean duration of hospital stay was 2.7 ± 0.7 days in cases delivered vaginally and 7.5 ± 1.6 days in those who underwent cesarean section in group A, while it was 4.04 ± 1.47 and 11.11 ± 3.14 days, respectively, in group B.
Conclusion
Short-course, i.e., 6-h, postpartum magnesium sulfate therapy is as effective as conventional 24-h postpartum magnesium sulfate therapy in preventing convulsions in severe preeclampsia.
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Acknowledgments
We take this opportunity to thank all the patients; without their willingness and co-operation, this would have been an incomplete accomplishment and our utmost appreciation to the Almighty God for the divine intervention in this academic endeavor. No financial support was provided for this study.
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Anjum, S., Rajaram, G.P. & Bano, I. Short-course postpartum (6-h) magnesium sulfate therapy in severe preeclampsia. Arch Gynecol Obstet 293, 983–986 (2016). https://doi.org/10.1007/s00404-015-3903-y
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DOI: https://doi.org/10.1007/s00404-015-3903-y