Archives of Gynecology and Obstetrics

, Volume 289, Issue 2, pp 269–273

Pregnancy outcome in patients with idiopathic thrombocytopenic purpura

  • Murali subbaiah
  • Sunesh kumar
  • Kallol Kumar Roy
  • Jai Bhagwan Sharma
  • Neeta Singh
Maternal-Fetal Medicine

DOI: 10.1007/s00404-013-2958-x

Cite this article as:
subbaiah, M., kumar, S., Roy, K.K. et al. Arch Gynecol Obstet (2014) 289: 269. doi:10.1007/s00404-013-2958-x

Abstract

Objective

To study the outcome of pregnancy in women with idiopathic thrombocytopenic purpura.

Materials and methods

A retrospective analysis of 30 pregnancies in 26 women with idiopathic thrombocytopenic purpura was carried out at a tertiary hospital in India. The courses of the disease, maternal and perinatal outcome in these pregnancies were studied.

Results

Mean age of pregnant women with idiopathic thrombocytopenic purpura was 27.3 years and 61.5 % was primigravidae. Out of 26 patients with idiopathic thrombocytopenic purpura, 16 were already diagnosed while the other 10 were diagnosed during pregnancy. The incidence of bleeding episodes in antenatal period, severe thrombocytopenia and hemorrhagic complications at the time of delivery was 30, 37 and 11.1 %, respectively. Oral steroids were required in 40 % of pregnancies. Two patients received intravenous immunoglobulin therapy. Severe thrombocytopenia at the time of delivery was more commonly seen in women in whom ITP was diagnosed during pregnancy as compared to those in whom ITP was diagnosed prior to pregnancy (P = 0.04). Severe thrombocytopenia was seen in 18.5 % of neonates and intracranial hemorrhage was detected in 1 neonate. There were no still births or maternal mortality.

Conclusion

Pregnancy outcome in patients with idiopathic thrombocytopenic purpura is generally good.

Keywords

Idiopathic thrombocytopenic purpuraPregnancy outcomeNeonatal thrombocytopeniaMaternal thrombocytopenia

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Murali subbaiah
    • 1
    • 2
  • Sunesh kumar
    • 1
  • Kallol Kumar Roy
    • 1
  • Jai Bhagwan Sharma
    • 1
  • Neeta Singh
    • 1
  1. 1.Department of Obstetrics and GynecologyAll India Institute of Medical SciencesNew DelhiIndia
  2. 2.Department of Obstetrics and GynecologyAll India Institute of Medical SciencesBangaloreIndia