Archives of Gynecology and Obstetrics

, Volume 288, Issue 4, pp 747–757

Ectopic pregnancy: a review

Reproductive Medicine

DOI: 10.1007/s00404-013-2929-2

Cite this article as:
Rana, P., Kazmi, I., Singh, R. et al. Arch Gynecol Obstet (2013) 288: 747. doi:10.1007/s00404-013-2929-2

Abstract

Purpose

Ectopic pregnancy (EP) presents a major health problem for women of child-bearing age. EP refers to the pregnancy occurring outside the uterine cavity that constitutes 1.2–1.4 % of all reported pregnancies. All identified risk factors are maternal: pelvic inflammatory disease, Chlamydia trachomatis infection, smoking, tubal surgery, induced conception cycle, and endometriosis. These developments have provided the atmosphere for trials using methotrexate as a non-surgical treatment for EP. The diagnosis measure of EP is serum human chorionic gonadotropin, urinary hCGRP/i-hCG, progesterone measurement, transvaginal ultrasound scan, computed tomography, vascular endothelial growth factor, CK, disintegrin and metalloprotease-12 and hysterosalpingography. The treatment option of EP involves surgical treatment by laparotomy or laparoscopy, medical treatment is usually systemic or through local route, or by expectant treatment.

Results

It was concluded that review data reflect a decrease in surgical treatment and not an actual decline in EP occurrence so that further new avenues are needed to explore early detection of the EP.

Keywords

β-hCGTVSMethotrexateLaparotomy

Abbreviations

EP

Ectopic pregnancy

CEP

Cervical ectopic pregnancy

OEP

Ovarian ectopic pregnancy

CSEP

Cesarean scar ectopic pregnancy

IP

Interstitial pregnancy

PID

Pelvic inflammatory disease

PROKR

Prokineticin receptor

IVF

In vitro fertilization

ART

Assisted reproductive technology

β-hCG

Serum human chorionic gonadotropin

TVS

Transvaginal ultrasound scan

CT

Computed tomography

VEGF

Vascular endothelial growth factor

ADAM-12

Disintegrin and metalloprotease-12

Hsg

Hysterosalpingography

MTX

Methotrexate

PPV

Positive predictive value

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Siddhartha Institute of PharmacyDehradunIndia
  2. 2.Department of Biochemistry, Faculty of ScienceKing Abdulaziz UniversityJeddahSaudi Arabia
  3. 3.Lab Director, Jeddah Eye HospitalMinistry of HealthJeddahSaudi Arabia
  4. 4.Alchemist HospitalPanchkulaIndia