Archives of Gynecology and Obstetrics

, Volume 288, Issue 3, pp 627–633

Is Chlamydia trachomatis related to human papillomavirus infection in young women of southern European population? A self-sampling study

  • Jani Silva
  • Fátima Cerqueira
  • Joana Ribeiro
  • Hugo Sousa
  • Teresa Osório
  • Rui Medeiros
Gynecologic Oncology

DOI: 10.1007/s00404-013-2771-6

Cite this article as:
Silva, J., Cerqueira, F., Ribeiro, J. et al. Arch Gynecol Obstet (2013) 288: 627. doi:10.1007/s00404-013-2771-6

Abstract

Background

It is well established the role of human papillomavirus (HPV) in cervical cancer (CC) etiology. Chlamydia trachomatis (CT) infection seems to synergize with HPV in CC multistage process. The aim of this study was to assess the correlation of HPV and CT infection in young student women.

Material and methods

Cervicovaginal samples were obtained by self-sampling method from young women (n = 432; mean age 18.0 ± 2.46 years) recruited among the student community and tested for HPV and CT DNA by polymerase chain reaction.

Results

In CT positive cases, there is an increased risk of HPV detection [odds ratio (OR) 2.4, 95 % confidence interval (CI) 1.03–6.27, p < 0.037]. The highest rate of coinfection with HPV and CT were observed in the mean age of 20.6 years, and all coinfection cases were found in young women who referred no previous history or symptoms of sexually transmitted infections. Within HPV-positive young women, there was no significant difference between CT and high-risk HPV.

Conclusions

Our results suggest a causal association between HPV and CT infection in young women; infection with this bacterium may be a predisposing factor for subsequent infection with HPV, or vice versa, due to similar mode of sexual transmission, inferring the promising role of CT in CC development. However, the specific question on multistage process of HPV-associated carcinogenesis, which may be affected by CT, remains unclear.

Keywords

Chlamydia trachomatis Human papillomavirus Cervical cancer Young women 

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Jani Silva
    • 1
    • 4
    • 5
    • 8
    • 2
  • Fátima Cerqueira
    • 5
    • 7
  • Joana Ribeiro
    • 1
    • 3
    • 2
  • Hugo Sousa
    • 1
    • 3
    • 2
  • Teresa Osório
    • 8
  • Rui Medeiros
    • 1
    • 3
    • 5
    • 6
    • 8
    • 2
  1. 1.Molecular Oncology GRPPortuguese Institute of Oncology (IPO Porto)PortoPortugal
  2. 2.Rua Dr. António Bernardino AlmeidaPortoPortugal
  3. 3.Molecular Biology Laboratory-Virology ServicePortuguese Institute of OncologyPortoPortugal
  4. 4.Faculty of MedicineUniversity of PortoPortoPortugal
  5. 5.CEBIMED, Faculty of Health SciencesFernando Pessoa UniversityPortoPortugal
  6. 6.ICBAS, Abel Salazar Institute for the Biomedical SciencesUniversity of PortoPortoPortugal
  7. 7.CEQUIMED, Faculty of PharmacyUniversity of PortoPortoPortugal
  8. 8.LPCC, Research DepartmentPortuguese League Against Cancer (LPCC-NRNorte)PortoPortugal